Serotonin and Pulmonary Hypertension; Sex and Drugs and ROCK and Rho.
Sign Up to like & getrecommendations! Published in 2022 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c220004
Abstract: Serotonin is often referred to as a "happy hormone" as it maintains good mood, well-being, and happiness. It is involved in communication between nerve cells and plays a role in sleeping and digestion. However, too… read more here.
Keywords: serotonin; pulmonary hypertension; hypertension; serotonin synthesis ... See more keywords
Dual Roles for the TSPYL Family in Mediating Serotonin Transport and the Metabolism of Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1692
Abstract: We previously reported that testis‐specific Y‐encoded‐like protein (TSPYLs) are transcription regulators for CYP3A4, CYP2C9, and CYP2C19. Here, we observed dual roles for TSPYLs in mediating serotonin transport and the metabolism of selective serotonin reuptake inhibitors… read more here.
Keywords: metabolism; mediating serotonin; serotonin; serotonin transport ... See more keywords
Trait Openness and serotonin 2A receptors in healthy volunteers: A positron emission tomography study
Sign Up to like & getrecommendations! Published in 2019 at "Human Brain Mapping"
DOI: 10.1002/hbm.24511
Abstract: Recent research found lasting increases in personality trait Openness in healthy individuals and patients after administration of the serotonin 2A receptor (5‐HT2AR) agonist psilocybin. However, no studies have investigated whether 5‐HT2AR availability as imaged using… read more here.
Keywords: openness; serotonin; trait openness; positron emission ... See more keywords
Postnatal depletion of serotonin affects the morphology of neurons and the function of the hippocampus in male rats
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10174
Abstract: Serotonin (5‐HT) is an essential neurotransmitter for the refined organization of the cerebral cortex. Studies have suggested that altered serotonin signaling contributes to cognitive impairment and psychiatric disorders. However, the exact role of this neurotransmitter… read more here.
Keywords: serotonin; postnatal depletion; serotonin affects; morphology neurons ... See more keywords
Serotonin axons in the neocortex of the adult female mouse regrow after traumatic brain injury
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24059
Abstract: It is widely held that injured neurons in the central nervous system do not undergo axonal regrowth. However, there is mounting evidence that serotonin axons are a notable exception. Serotonin axons undergo long‐distance regrowth in… read more here.
Keywords: serotonin axons; traumatic brain; serotonin; density ... See more keywords
A trial design to maximize knowledge of the effects of rodatristat ethyl in the treatment of pulmonary arterial hypertension (ELEVATE 2)
Sign Up to like & getrecommendations! Published in 2022 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12088
Abstract: Abstract Serotonin plays a key role in the development and maintenance of the pathobiology associated with pulmonary arterial hypertension (PAH). Platelet‐driven and locally produced serotonin from lung tissue and arterial endothelial cells induce excessive growth… read more here.
Keywords: serotonin; rodatristat ethyl; arterial hypertension; trial ... See more keywords
Depression and Serum Content of Serotonin in Adult Patients with Atopic Dermatitis.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2019_470
Abstract: Atopic dermatitis (AD) is a chronic skin disease with the etiology not yet conclusively established. Recent reports demonstrate the role of serotonin (5-hydroxytryptamine; 5-HT) in the pathogenesis of AD. The aim of this study was… read more here.
Keywords: depression; serotonin; content serotonin; atopic dermatitis ... See more keywords
Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-4874-z
Abstract: RationaleAberrant glutamatergic, dopaminergic, and GABAergic neurotransmission has been implicated in schizophrenia. Cariprazine reverses the behavioral effects observed in the rat phencyclidine (PCP)-induced model of schizophrenia; however, little is known about its in vivo neurochemistry.ObjectivesThe study… read more here.
Keywords: cariprazine aripiprazole; serotonin; locomotor activity; extracellular levels ... See more keywords
Role of serotonin and norepinephrine transporters in antidepressant-induced arterial hypertension: a pharmacoepidemiological-pharmacodynamic study
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-020-02913-0
Abstract: Purpose Some reports have described arterial hypertension (AH) in patients treated by serotonin reuptake inhibitor (SRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressants. The mechanism remains discussed, some authors suggesting a role of SERT (SERotonin Transporter)… read more here.
Keywords: snri; arterial hypertension; serotonin; study ... See more keywords
Maternal chewing improves prenatal stress-induced cognitive deficit and anxiety-like behavior associated with alterations of the apoptotic response and serotonin pathway in mouse offspring.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2021.105245
Abstract: OBJECTIVE To examine whether maternal chewing affects prenatal stress-induced behavioral alternations associated with the changes in apoptosis-related proteins and serotonin pathway of the mouse offspring. DESIGN Pregnant mice were assigned to control, stress, and stress/chewing… read more here.
Keywords: prenatal stress; like behavior; anxiety like; serotonin ... See more keywords
Neonatal fluoxetine exposure modulates serotonergic neurotransmission and disturb inhibitory action of serotonin on food intake
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.07.038
Abstract: &NA; The neurotransmitter serotonin (5‐HT) acts as an important regulator of the critical neurodevelopmental processes and thus alterations in 5‐HT signaling early promotes permanent structural and functional changes in brain. The selective serotonin reuptake inhibitors… read more here.
Keywords: disturb inhibitory; food intake; exposure; serotonin ... See more keywords