Blood phenylalanine reduction corrects CNS dopamine and serotonin deficiencies and partially improves behavioral performance in adult phenylketonuric mice.
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DOI: 10.1016/j.ymgme.2017.10.009
Abstract: Central nervous system (CNS) deficiencies of the monoamine neurotransmitters dopamine and serotonin have been implicated in the pathophysiology of neuropsychiatric dysfunction in human phenylketonuria (PKU). In this study, we confirmed the occurrence of brain dopamine… read more here.
Keywords: dopamine serotonin; phenylalanine; serotonin deficiencies; mice ... See more keywords