Neonatal Serotonin Depletion Induces Hyperactivity and Anxiolytic-like Sex-Dependent Effects in Adult Rats.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular neurobiology"
DOI: 10.1007/s12035-020-02181-0
Abstract: The serotoninergic system plays an important role in the ontogeny of the mammalian central nervous system, and changes in serotonin production during development may lead to permanent changes in brain cytoarchitecture and function. The present… read more here.
Keywords: neonatal serotonin; adult rats; serotonin depletion; depletion ... See more keywords
Serotonin depletion increases seizure susceptibility and worsens neuropathological outcomes in kainate model of epilepsy
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DOI: 10.1016/j.brainresbull.2017.07.009
Abstract: Serotonin is implicated in the regulation of seizures, but whether or not it can potentiate the effects of epileptogenic factors is not fully established. Using the kainic acid model of epilepsy in rats, we tested… read more here.
Keywords: kainic acid; serotonin; pretreated rats; serotonin depletion ... See more keywords
Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Psychiatry"
DOI: 10.1038/s41380-021-01240-9
Abstract: Serotonin is involved in updating responses to changing environmental circumstances. Optimising behaviour to maximise reward and minimise punishment may require shifting strategies upon encountering new situations. Likewise, autonomic responses to threats are critical for survival… read more here.
Keywords: serotonin depletion; reversal; depletion impairs; reversal learning ... See more keywords