Reduced Vesicular Acetylcholine Transporter favors antidepressant behaviors and modulates serotonin and dopamine in female mouse brain
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.04.049
Abstract: &NA; Depression is extremely harmful to modern society. Despite its complex spectrum of symptoms, previous studies have mostly focused on the monaminergic system in search of pharmacological targets. However, other neurotransmitter systems have also been… read more here.
Keywords: acetylcholine transporter; vesicular acetylcholine; depressive like; serotonin dopamine ... See more keywords
In Vitro and In Vivo Characterization of PCC0104005, a Novel Modulator of Serotonin-Dopamine Activity, as an Atypical Antipsychotic Drug
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-25036-0
Abstract: PCC0104005 is a novel drug candidate for treating schizophrenia that displays high affinity for serotonin, dopamine, and noradrenaline receptors, including partial agonism at dopamine D2, D3, D4, serotonin 5-HT1A, and 5-HT2A receptors and antagonism at… read more here.
Keywords: pcc0104005 novel; dopamine; drug; pcc0104005 ... See more keywords
The Serotonin-Dopamine Relationship on the Aggression-Suicidal Risk Axis in Patients with Major Depression Disorder: Describing Some Social Implications
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DOI: 10.33788/rcis.65.8
Abstract: In the present report we want it to see if there is a connection between serotonin and/or dopamine and the aggression-suicidal risk axis in patients with major depression disorders. 113 patients were selected and we… read more here.
Keywords: serotonin dopamine; depression; aggression suicidal; risk ... See more keywords
Efficacy of Serotonin and Dopamine Activity Modulators in the Treatment of Negative Symptoms in Schizophrenia: A Rapid Review
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11030921
Abstract: Schizophrenia is among the fifteen most disabling diseases worldwide. Negative symptoms (NS) are highly prevalent in schizophrenia, negatively affect the functional outcome of the disorder, and their treatment is difficult and rarely specifically investigated. Serotonin-dopamine… read more here.
Keywords: rapid review; negative symptoms; serotonin dopamine; dopamine activity ... See more keywords