Adenosine Monophosphate-activated Protein Kinase (AMPK) in serotonin neurons mediates select behaviors during protracted withdrawal from morphine in mice
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113688
Abstract: Serotonin neurotransmission has been implicated in behavior deficits that occur during protracted withdrawal from opioids. In addition, studies have highlighted multiple pathways whereby serotonin (5-HT) modulates energy homeostasis, however the underlying metabolic effects of opioid… read more here.
Keywords: morphine; mice; serotonin; serotonin neurons ... See more keywords
Serotonin neurons modulate learning rate through uncertainty
Sign Up to like & getrecommendations! Published in 2022 at "Current Biology"
DOI: 10.1016/j.cub.2021.12.006
Abstract: Regulating how fast to learn is critical for flexible behavior. Learning about the consequences of actions should be slow in stable environments, but accelerate when that environment changes. Recognizing stability and detecting change are difficult… read more here.
Keywords: modulate learning; meta learning; serotonin; serotonin neurons ... See more keywords
Voltammetric Approach for Characterizing the Biophysical and Chemical Functionality of Human Induced Pluripotent Stem Cell-Derived Serotonin Neurons.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c05082
Abstract: Depression is quickly becoming one of the world's most pressing public health crises, and there is an urgent need for better diagnostics and therapeutics. Behavioral models in animals and humans have not adequately addressed the… read more here.
Keywords: vivo; pluripotent stem; induced pluripotent; serotonin neurons ... See more keywords
Patch-to-Seq and Transcriptomic Analyses Yield Molecular Markers of Functionally Distinct Brainstem Serotonin Neurons
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2022.910820
Abstract: Acute regulation of CO2 and pH homeostasis requires sensory feedback from peripheral (carotid body) and central (central) CO2/pH sensitive cells – so called respiratory chemoreceptors. Subsets of brainstem serotonin (5-HT) neurons in the medullary raphe… read more here.
Keywords: brainstem serotonin; patch seq; functionally distinct; co2 sensitive ... See more keywords
Inhibitory peptidergic modulation of C. elegans serotonin neurons is gated by T-type calcium channels
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.22771
Abstract: Serotonin is an evolutionarily ancient molecule that functions in generating and modulating many behavioral states. Although much is known about how serotonin acts on its cellular targets, how serotonin release is regulated in vivo remains… read more here.
Keywords: modulation; calcium channels; type calcium; serotonin neurons ... See more keywords