Enhanced Expression of Serotonin Receptor 5-Hydroxytryptamine 2C is Associated with Increased Feather Damage in Dongxiang Blue-Shelled Layers
Sign Up to like & getrecommendations! Published in 2017 at "Behavior Genetics"
DOI: 10.1007/s10519-017-9839-1
Abstract: The gene encoding the serotonin receptor 5-hydroxytraptamine 2C (HTR2C) has been implicated in behavioral phenotypes in a number of species. In previous studies, a mutation in the chicken HTR2C gene was found to be associated… read more here.
Keywords: dongxiang blue; blue shelled; feather damage; expression ... See more keywords
Does the serotonin receptor gene (rs6313 and rs6314) polymorphism have a role in suicidal attempts?
Sign Up to like & getrecommendations! Published in 2018 at "Journal of forensic and legal medicine"
DOI: 10.1016/j.jflm.2018.03.006
Abstract: Suicide is an important public health problem. The aim of the present study is to determine the incidence of serotonin receptor gene polymorphisms (rs6313and rs6314) in patients with a history of suicide attempt by blood… read more here.
Keywords: group; serotonin receptor; genotype genotype; receptor gene ... See more keywords
Pharmacogenetics analysis of serotonin receptor gene variants and clinical response to risperidone in Han Chinese schizophrenic patients
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.08.002
Abstract: Assessments of the pharmacological profiles of antipsychotic agents have shown that the serotonin receptor family is often involved in their pharmacodynamics. Response to antipsychotic therapy is highly variable, yet prognostic biomarkers are lacking. The aim… read more here.
Keywords: han chinese; serotonin receptor; response; risperidone ... See more keywords
Dopamine requires unique residues to signal via the serotonin 2A receptor
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.03.056
Abstract: Serotonin is an important neurotransmitter and neuromodulator. Disruption of the serotonergic system has been implicated in various psychiatric disorders such as schizophrenia and bipolar disorder. Most of the drugs targeting these neurotransmitter systems are classified… read more here.
Keywords: dopamine requires; dopamine; serotonin receptor; receptor ... See more keywords
General Metadynamics Protocol To Simulate Activation/Deactivation of Class A GPCRs: Proof of Principle for the Serotonin Receptor.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00208
Abstract: We present a generally applicable metadynamics protocol for characterizing the activation free-energy profiles of class A G-protein coupled receptors and a proof-of-principle study for the 5HT1A-receptor. The almost universal A100 activation index, which depends on… read more here.
Keywords: proof principle; class; serotonin receptor; metadynamics protocol ... See more keywords
Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02031
Abstract: The 5-HT5A receptor (5-HT5AR), for which no selective agonists and a few antagonists exist, remains the least understood serotonin receptor. A single commercial antagonist, SB-699551, has been widely used to investigate the 5-HT5AR function in… read more here.
Keywords: chemical probe; probe; structure based; serotonin receptor ... See more keywords
Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11936-w
Abstract: Anesthetics are generally associated with sedation, but some anesthetics can also increase brain and motor activity—a phenomenon known as paradoxical excitation. Previous studies have identified GABAA receptors as the primary targets of most anesthetic drugs,… read more here.
Keywords: paradoxical excitation; sedation; receptor ligands; serotonin receptor ... See more keywords
Serotonin-1A receptor C-1019G polymorphism affects brain functional networks
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12913-3
Abstract: The serotonin-1A (5-HT1A) receptor is strongly implicated in major depression and other affective disorders due to its negative regulation of serotonin neurone firing rates. Behavioural and clinical studies have repeatedly reported that the −1019G allele… read more here.
Keywords: brain networks; affective disorders; serotonin receptor; receptor ... See more keywords
In silico decryption of serotonin–receptor binding: local non-covalent interactions and long-range conformational changes
Sign Up to like & getrecommendations! Published in 2020 at "RSC Advances"
DOI: 10.1039/d0ra05559j
Abstract: Serotonin–receptor binding is the key step in the process behind serotonin functionality, including several psychological and physiological behaviours. This study is focused on identifying the main non-covalent interactions controlling the stability of serotonin–receptor complexes as… read more here.
Keywords: non covalent; serotonin; serotonin receptor; covalent interactions ... See more keywords
Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of animal science"
DOI: 10.1093/jas/sky038
Abstract: Prior work using a contractility bioassay determined that the serotonin (5-HT) receptor subtype 5-HT2A is present in bovine lateral saphenous veins and plays a role in ergot alkaloid (EA)-induced vascular contraction in steers grazing endophyte-infected… read more here.
Keywords: vasculature; bovine; ruminal mesenteric; serotonin receptor ... See more keywords
The serotonin 2A receptor agonist TCB‐2 attenuates heavy alcohol drinking and alcohol‐induced midbrain inhibitory plasticity
Sign Up to like & getrecommendations! Published in 2022 at "Addiction Biology"
DOI: 10.1111/adb.13147
Abstract: Disruption of neuronal chloride ion (Cl−) homeostasis has been linked to several pathological conditions, including substance use disorder, yet targeted pharmacotherapies are lacking. In this study, we explored the potential of serotonin 2A receptor (5‐HT2AR)… read more here.
Keywords: alcohol consumption; serotonin receptor; alcohol induced; alcohol ... See more keywords