Enhanced Expression of Serotonin Receptor 5-Hydroxytryptamine 2C is Associated with Increased Feather Damage in Dongxiang Blue-Shelled Layers
Sign Up to like & getrecommendations! Published in 2017 at "Behavior Genetics"
DOI: 10.1007/s10519-017-9839-1
Abstract: The gene encoding the serotonin receptor 5-hydroxytraptamine 2C (HTR2C) has been implicated in behavioral phenotypes in a number of species. In previous studies, a mutation in the chicken HTR2C gene was found to be associated… read more here.
Keywords: dongxiang blue; blue shelled; feather damage; expression ... See more keywords
Does the serotonin receptor gene (rs6313 and rs6314) polymorphism have a role in suicidal attempts?
Sign Up to like & getrecommendations! Published in 2018 at "Journal of forensic and legal medicine"
DOI: 10.1016/j.jflm.2018.03.006
Abstract: Suicide is an important public health problem. The aim of the present study is to determine the incidence of serotonin receptor gene polymorphisms (rs6313and rs6314) in patients with a history of suicide attempt by blood… read more here.
Keywords: group; serotonin receptor; genotype genotype; receptor gene ... See more keywords
Pharmacogenetics analysis of serotonin receptor gene variants and clinical response to risperidone in Han Chinese schizophrenic patients
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.08.002
Abstract: Assessments of the pharmacological profiles of antipsychotic agents have shown that the serotonin receptor family is often involved in their pharmacodynamics. Response to antipsychotic therapy is highly variable, yet prognostic biomarkers are lacking. The aim… read more here.
Keywords: han chinese; serotonin receptor; response; risperidone ... See more keywords
Dopamine requires unique residues to signal via the serotonin 2A receptor
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.03.056
Abstract: Serotonin is an important neurotransmitter and neuromodulator. Disruption of the serotonergic system has been implicated in various psychiatric disorders such as schizophrenia and bipolar disorder. Most of the drugs targeting these neurotransmitter systems are classified… read more here.
Keywords: dopamine requires; dopamine; serotonin receptor; receptor ... See more keywords
General Metadynamics Protocol To Simulate Activation/Deactivation of Class A GPCRs: Proof of Principle for the Serotonin Receptor.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00208
Abstract: We present a generally applicable metadynamics protocol for characterizing the activation free-energy profiles of class A G-protein coupled receptors and a proof-of-principle study for the 5HT1A-receptor. The almost universal A100 activation index, which depends on… read more here.
Keywords: proof principle; class; serotonin receptor; metadynamics protocol ... See more keywords
Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02031
Abstract: The 5-HT5A receptor (5-HT5AR), for which no selective agonists and a few antagonists exist, remains the least understood serotonin receptor. A single commercial antagonist, SB-699551, has been widely used to investigate the 5-HT5AR function in… read more here.
Keywords: chemical probe; probe; structure based; serotonin receptor ... See more keywords
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.3c02148
Abstract: Alzheimer’s disease (AD) has a complex and not-fully-understood etiology. Recently, the serotonin receptor 5-HT6 emerged as a promising target for AD treatment; thus, here a new series of 5-HT6R ligands with a 1,3,5-triazine core and… read more here.
Keywords: alzheimer disease; receptor ht6; serotonin receptor;
Advances in Psychoactive Alkaloid Delivery, Ergoline Analogues, and Serotonin Receptor Modulation for Enhanced Therapeutic Outcomes.
Sign Up to like & getrecommendations! Published in 2024 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.4c00586
Abstract: Recent advancements in pharmaceutical research have focused on developing novel psychoactive compounds and receptor modulators that enhance therapeutic outcomes while minimizing adverse effects. This Patent Highlight examines three innovative approaches: (1) transmucosal delivery of dephosphorylated… read more here.
Keywords: receptor; advances psychoactive; therapeutic outcomes; ergoline analogues ... See more keywords
Long-Chain Cyclic Arylguanidines as Multifunctional Serotonin Receptor Ligands with Antiproliferative Activity
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.4c06456
Abstract: Recent investigations have shown serotonin’s stimulatory effect on several types of cancers and carcinoid tumors. Nowadays there has been a significant increase in interest in 5-HT7 and 5-HT5A receptors in the context of cancer treatment.… read more here.
Keywords: multifunctional serotonin; receptor ligands; ht6r; long chain ... See more keywords
Relationship between cortical thickness and serotonin 1A receptor binding in bipolar disorder
Sign Up to like & getrecommendations! Published in 2025 at "Translational Psychiatry"
DOI: 10.1038/s41398-025-03642-7
Abstract: Deficits in cortical thickness have been a replicated finding in BD. Greater brain serotonin 1 A receptor (5HT1AR) binding has also been reported in BD, consistent with a disruption in serotonin signaling. Serotonin can cause a… read more here.
Keywords: 11c way100635; thickness; cortical thickness; serotonin receptor ... See more keywords
Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11936-w
Abstract: Anesthetics are generally associated with sedation, but some anesthetics can also increase brain and motor activity—a phenomenon known as paradoxical excitation. Previous studies have identified GABAA receptors as the primary targets of most anesthetic drugs,… read more here.
Keywords: paradoxical excitation; sedation; receptor ligands; serotonin receptor ... See more keywords