Serotonin receptors in epilepsy: Novel treatment targets?
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia Open"
DOI: 10.1002/epi4.12580
Abstract: Despite the availability of over 30 antiseizure medications (ASMs), there is no “one size fits it all,” so there is a continuing search for novel ASMs. There are divergent data demonstrating that modulation of distinct… read more here.
Keywords: novel treatment; epilepsy novel; receptors epilepsy; serotonin receptors ... See more keywords
Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.05.023
Abstract: Rewiring of synaptic circuitry pertinent to memory formation has been associated with morphological changes in dendritic spines and with extracellular matrix (ECM) remodeling. Here, we mechanistically link these processes by uncovering a signaling pathway involving… read more here.
Keywords: depends signaling; extracellular matrix; serotonin receptors; synaptic remodeling ... See more keywords
Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors
Sign Up to like & getrecommendations! Published in 2023 at "Science"
DOI: 10.1126/science.adf0435
Abstract: Decreased dendritic spine density in the cortex is a hallmark of several neuropsychiatric diseases, and the ability to promote cortical neuron growth has been hypothesized to underlie the rapid and sustained therapeutic effects of psychedelics.… read more here.
Keywords: serotonin; neuroplasticity activation; serotonin receptors; activation intracellular ... See more keywords
Serotonin 2 Receptors, Agomelatine, and Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Neurology"
DOI: 10.1155/2021/5533827
Abstract: There are nearly 50 million Alzheimer's disease (AD) patients worldwide, 90% of whom develop behavioral and psychological symptoms of dementia (BPSD), which increase the mortality rate of patients, and impose an economic and care burden… read more here.
Keywords: symptoms dementia; behavioral psychological; psychological symptoms; alzheimer disease ... See more keywords
First quantitative dosages: Strong correlations between non-5-HT2Rs serotonin receptors on normal human heart valves
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.897657
Abstract: Objectives Although critical in animal and human development and pathology, a measurement of the quantitative expression of 5-HTR serotonin receptors on animal or human valvular tissues has never been performed. Methods Quantification of the most… read more here.
Keywords: ht2ar ht2br; expression; non ht2rs; serotonin receptors ... See more keywords
Ergotamine Stimulates Human 5-HT4-Serotonin Receptors and Human H2-Histamine Receptors in the Heart
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054749
Abstract: Ergotamine (2′-methyl-5′α-benzyl-12′-hydroxy-3′,6′,18-trioxoergotaman) is a tryptamine-related alkaloid from the fungus Claviceps purpurea. Ergotamine is used to treat migraine. Ergotamine can bind to and activate several types of 5-HT1-serotonin receptors. Based on the structural formula of ergotamine,… read more here.
Keywords: ht4 serotonin; histamine receptors; receptors human; serotonin receptors ... See more keywords
Cardiac Roles of Serotonin (5-HT) and 5-HT-Receptors in Health and Disease
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054765
Abstract: Serotonin acts solely via 5-HT4-receptors to control human cardiac contractile function. The effects of serotonin via 5-HT4-receptors lead to positive inotropic and chronotropic effects, as well as arrhythmias, in the human heart. In addition, 5-HT4-receptors… read more here.
Keywords: ht4; ht4 receptors; cardiac roles; serotonin receptors ... See more keywords
Marine Inspired 2-(5-Halo-1H-indol-3-yl)-N,N-dimethylethanamines as Modulators of Serotonin Receptors: An Example Illustrating the Power of Bromine as Part of the Uniquely Marine Chemical Space
Sign Up to like & getrecommendations! Published in 2017 at "Marine Drugs"
DOI: 10.3390/md15080248
Abstract: In previous studies, we have isolated several marine indole alkaloids and evaluated them in the forced swim test (FST) and locomotor activity test, revealing their potential as antidepressant and sedative drug leads. Amongst the reported… read more here.
Keywords: indol dimethylethanamine; chemical space; serotonin receptors; part ... See more keywords