Toxicities of opioid analgesics: respiratory depression, histamine release, hemodynamic changes, hypersensitivity, serotonin toxicity.
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DOI: 10.1007/s00204-021-03068-2
Abstract: Opioid-induced respiratory depression is potentially life-threatening and often regarded as the main hazard of opioid use. Main cause of death is cardiorespiratory arrest with hypoxia and hypercapnia. Respiratory depression is mediated by opioid μ receptors… read more here.
Keywords: histamine; toxicity; hemodynamic changes; respiratory depression ... See more keywords
Desvenlafaxine overdose and the occurrence of serotonin toxicity, seizures and cardiovascular effects
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DOI: 10.1080/15563650.2016.1223847
Abstract: Abstract Context: Desvenlafaxine is used to treat major depression. Desvenlafaxine is also the active metabolite of venlafaxine. Venlafaxine overdose can cause serotonin toxicity, seizures and cardiovascular effects, but there is limited information on desvenlafaxine overdose.… read more here.
Keywords: desvenlafaxine overdose; desvenlafaxine; serotonin toxicity; toxicity seizures ... See more keywords
Duloxetine overdose causes sympathomimetic and serotonin toxicity without major complications
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DOI: 10.1080/15563650.2022.2083631
Abstract: Abstract Objective Duloxetine is a commonly used antidepressant that is a serotonin and norepinephrine reuptake inhibitor. We aimed to investigate the frequency and severity of clinical effects following duloxetine overdose. Methods We undertook a retrospective… read more here.
Keywords: toxicology; duloxetine overdose; toxicity; serotonin toxicity ... See more keywords
Predicting serotonin toxicity in serotonin reuptake inhibitor overdose
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DOI: 10.1080/15563650.2022.2151455
Abstract: Abstract Aims We aimed to investigate the frequency of serotonin toxicity following overdose of antidepressants that inhibit serotonin reuptake and the factors that influence the probability of serotonin toxicity occurring. Methods This was a retrospective… read more here.
Keywords: toxicology; toxicity; serotonin reuptake; serotonin toxicity ... See more keywords