Dual Roles for the TSPYL Family in Mediating Serotonin Transport and the Metabolism of Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder
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DOI: 10.1002/cpt.1692
Abstract: We previously reported that testis‐specific Y‐encoded‐like protein (TSPYLs) are transcription regulators for CYP3A4, CYP2C9, and CYP2C19. Here, we observed dual roles for TSPYLs in mediating serotonin transport and the metabolism of selective serotonin reuptake inhibitors… read more here.
Keywords: metabolism; mediating serotonin; serotonin; serotonin transport ... See more keywords
Abstract 122: Novel role of SLC22A3 in serotonin transport and subsequent regulation of the pancreatic cancer stemness machinery
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DOI: 10.1158/1538-7445.am2025-122
Abstract: Cancer stem cells (CSCs) are a small subpopulation within tumors that possess self-renewal and differentiation capabilities, driving tumor recurrence, therapy resistance, disease aggressiveness, and metastasis. In pancreatic cancer (PC), the mechanisms governing CSC self-renewal remain… read more here.
Keywords: cancer; serotonin transport; slc22a3 oct3; pancreatic cancer ... See more keywords