Serotonin transporter gene (SLC6A4) variation and sensory processing sensitivity—Comparison with other anxiety‐related temperamental dimensions
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1352
Abstract: Abstract Background The short (s) allele of the 5‐HTTLPR polymorphism in the promoter region of the human serotonin transporter (5‐HTT) gene SLC6A4 has previously been associated with anxiety‐related personality dimensions. However, this relationship has not… read more here.
Keywords: anxiety related; serotonin transporter; anxiety; httlpr rs25531 ... See more keywords
Serotonin 5-HT1B receptor-mediated behavior and binding in mice with the overactive and dysregulated serotonin transporter Ala56 variant.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05758-8
Abstract: RATIONALE Elevated whole-blood serotonin (5-HT) is a robust biomarker in ~ 30% of patients with autism spectrum disorders, in which repetitive behavior is a core symptom. Furthermore, elevated whole-blood 5-HT has also been described in patients… read more here.
Keywords: receptor; mice; serotonin transporter; ht1b receptor ... See more keywords
Serotonin transporter gene and escitalopram: depressing medical science
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-020-02945-6
Abstract: The clinical trial evaluating 5HTTLPR and 5HTTLPR-rs25531 polymorphisms with the treatment response of escitalopram in patients with major depressive disorder deserved comment [1]. Firstly, could Mandal and colleagues provide the trial registration number? According to… read more here.
Keywords: serotonin transporter; trial; gene escitalopram; transporter gene ... See more keywords
The serotonin transporter gene could play a role in anti-predator behaviour in a forest passerine
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Ethology"
DOI: 10.1007/s10164-019-00593-7
Abstract: Elucidating associations between behavioural variation and genes may help to understand the co-existence of different behavioural phenotypes in natural populations. In birds, two main candidate genes are known to affect exploratory and risk-taking behaviour through… read more here.
Keywords: serotonin transporter; transporter gene; anti predator; predator ... See more keywords
Serotonin transporter is negatively associated with body mass index after glucose loading in humans.
Sign Up to like & getrecommendations! Published in 2022 at "Brain imaging and behavior"
DOI: 10.1007/s11682-021-00600-x
Abstract: Serotonin transporter (SERT) is a presynaptically localized membrane protein that regulates the serotonin transmission via its reuptake of released serotonin. We hypothesized that glucose loading may change SERT availability from brainstem in humans. An intravenous… read more here.
Keywords: loading humans; serotonin transporter; mass index; glucose loading ... See more keywords
Serotonin Transporter Regulation by Cholesterol-Independent Lipid Signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114349
Abstract: Serotonin neurotransmission is largely governed by the regulation of the serotonin transporter (SERT). SERT is modulated in part by cholesterol, but the role of cholesterol and lipid signaling intermediates in regulating SERT are unknown. Serotonergic… read more here.
Keywords: serotonin transporter; lipid signaling; cholesterol; cholesterol independent ... See more keywords
Computational Investigation of the Serotonin Transporter Conformation and Reset Mechanism
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.712
Abstract: The aid of monoamine transporter (MAT) proteins in terminating the effect of neurotransmitters in the synaptic cleft is crucial for the maintenance of proper neurotransmitter concentrations. Termination of effect is achieved via the process of… read more here.
Keywords: serotonin transporter; system; mechanism; serotonin ... See more keywords
The Substrate Import Mechanism of the Human Serotonin Transporter.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical journal"
DOI: 10.1016/j.bpj.2022.01.024
Abstract: The serotonin transporter, SERT, initiates the reuptake of extracellular serotonin in the synapse to terminate neurotransmission. The cryo-EM structures of SERT bound to ibogaine and the physiological substrate serotonin resolved in different states provided a… read more here.
Keywords: serotonin transporter; serotonin; substrate import; substrate ... See more keywords
Platelet serotonin and serotonin transporter as peripheral surrogates in depression and anxiety patients
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.07.033
Abstract: ABSTRACT Previous studies suggested that serotonergic neurons and platelets share similarities in serotonin (5‐HT) uptake by serotonin transporter (SERT), storage, metabolism and release mechanisms, indicating that platelets may be used as a reliable peripheral surrogate… read more here.
Keywords: serotonin transporter; anxiety; anxiety patients; peripheral surrogates ... See more keywords
Serotonin transporter density in binge eating disorder and pathological gambling: A PET study with [11C]MADAM
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.09.007
Abstract: Behavioral addictions, such as pathological gambling (PG) and binge eating disorder (BED), appear to be associated with specific changes in brain dopamine and opioid function, but the role of other neurotransmitter systems is less clear.… read more here.
Keywords: eating disorder; serotonin transporter; binge eating; disorder ... See more keywords
Gender-specific association between serotonin transporter polymorphisms (5-HTTLPR and rs25531) and neuroticism, anxiety and depression in well-defined healthy Han Chinese.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2016.08.055
Abstract: BACKGROUND A tri-allelic serotonin transporter promoter polymorphism (5-HTTLPR/rs25531) more effectively determines the levels of transcriptional efficacy than that with the bi-allelic 5-HTTLPR polymorphism in vitro. Both are reportedly associated with personality traits of negative emotionality,… read more here.
Keywords: serotonin transporter; anxiety; httlpr rs25531; anxiety depression ... See more keywords