Role of Actin Cytoskeleton in Dynamics and Function of the Serotonin1A Receptor.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.08.034
Abstract: G protein-coupled receptors (GPCRs) are important membrane proteins in higher eukaryotes that carry out a vast array of cellular signaling and act as major drug targets. The serotonin1A receptor is a prototypical member of the… read more here.
Keywords: actin cytoskeleton; role actin; cytoskeleton dynamics; actin destabilization ... See more keywords
Exploring Endocytosis and Intracellular Trafficking of the Human Serotonin1A Receptor.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00033
Abstract: G protein-coupled receptors (GPCRs) represent the largest class of receptors involved in signal transduction across cell membranes and are major drug targets in all clinical areas. Endocytosis of GPCRs offers a regulatory mechanism for sustaining… read more here.
Keywords: serotonin1a receptor; human serotonin1a; endocytosis; receptor ... See more keywords
Synergistic and Competitive Lipid Interactions in the Serotonin1A Receptor Microenvironment.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00422
Abstract: The interaction of lipids with G-protein-coupled receptors (GPCRs) has been shown to modulate and dictate several aspects of GPCR organization and function. Diverse lipid interaction sites have been identified from structural biology, bioinformatics, and molecular… read more here.
Keywords: serotonin1a receptor; interaction sites; lipid interactions; cholesterol ... See more keywords
Exploring oligomeric state of the serotonin1A receptor utilizing photobleaching image correlation spectroscopy: implications for receptor function.
Sign Up to like & getrecommendations! Published in 2018 at "Faraday discussions"
DOI: 10.1039/c7fd00192d
Abstract: The oligomerization of G protein-coupled receptors (GPCRs) represents an important process in GPCR function and drug discovery. We have addressed cholesterol-dependent oligomerization state of the serotonin1A receptor, a representative GPCR and an important drug target,… read more here.
Keywords: state serotonin1a; serotonin1a receptor; spectroscopy; receptor ... See more keywords