Mapping the binding site of C1-inhibitor for polyanion cofactors.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.06.018
Abstract: The serpin, C1-inhibitor (also known as SERPING1), plays a vital anti-inflammatory role in the body by controlling pro-inflammatory pathways such as complement and coagulation. The inhibitor's action is enhanced in the presence of polyanionic cofactors,… read more here.
Keywords: polyanion; inhibitor; binding site; rate ... See more keywords
SERPIN A5 may have a potential as a biomarker in reflecting the improvement of semen quality in infertile men who underwent varicocele repair
Sign Up to like & getrecommendations! Published in 2021 at "Andrologia"
DOI: 10.1111/and.14081
Abstract: We aimed to identify proteins that were differentially regulated in spermatozoal samples collected from fertile healthy men (FHM) and infertile patients with varicocele (IFPV) before and after varicocelectomy. Seminal samples were collected from 20 IFPV… read more here.
Keywords: serpin; biomarker; semen quality; improvement semen ... See more keywords
The Serpin-tine Search for Factors Associated with COVID-19 Severity in Patients with Chronic Obstructive Pulmonary Disease
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202205-0956ed
Abstract: The coronavirus disease (COVID-19) pandemic, which has been driven by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has caused significant morbidity and mortality worldwide. With a range of clinical responses from asymptomatic to… read more here.
Keywords: serpin; protease; disease; infection ... See more keywords
Therapeutic SERPINs: Improving on Nature
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.648349
Abstract: Serine proteases drive important physiological processes such as coagulation, fibrinolysis, inflammation and angiogenesis. These proteases are controlled by serine protease inhibitors (SERPINs) that neutralize their activity. Currently, over 1,500 SERPINs are known in nature, but… read more here.
Keywords: protease; nature; therapeutic serpins; serpins improving ... See more keywords
Human Skin-Derived Mast Cells Spontaneously Secrete Several Angiogenesis-Related Factors
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01445
Abstract: Mast cells are classically recognized as cells that cause IgE-mediated allergic reactions. However, their ability to store and secrete vascular endothelial growth factor (VEGF) suggests a role in vascular development and tumorigenesis. The current study… read more here.
Keywords: skin derived; mast cells; angiogenesis related; human skin ... See more keywords
Iripin-1, a new anti-inflammatory tick serpin, inhibits leukocyte recruitment in vivo while altering the levels of chemokines and adhesion molecules
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1116324
Abstract: Serpins are widely distributed and functionally diverse inhibitors of serine proteases. Ticks secrete serpins with anti-coagulation, anti-inflammatory, and immunomodulatory activities via their saliva into the feeding cavity to modulate host’s hemostatic and immune reaction initiated… read more here.
Keywords: iripin; serpin; anti inflammatory; recruitment ... See more keywords
DNA accelerates the protease inhibition of a bacterial serpin chloropin
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1157186
Abstract: Serine protease inhibitors (Serpins) are the most widely distributed protease inhibitors in nature and have been identified from all kingdoms of life. Eukaryotic serpins are most abundant with their activities often subject to modulation by… read more here.
Keywords: inhibition; serpin; dna accelerates; chloropin ... See more keywords
Genome-Wide Characterization and Comparative Genomic Analysis of the Serpin Gene Family in Microsporidian Nosema bombycis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010550
Abstract: Microsporidia are ubiquitous in the environment, infecting almost all invertebrates, vertebrates, and some protists. The microsporidian Nosema bombycis causes silkworms pébrine disease and leads to huge economic losses. Parasite secreted proteins play vital roles in… read more here.
Keywords: serpin; comparative genomic; nosema; microsporidian nosema ... See more keywords
Elucidating the pathological mechanisms of neurodegeneration in the lethal serpinopathy FENIB
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.332142
Abstract: The term serpinopathies was introduced to describe a family of diseases caused by point mutations in serine protease inhibitors, or serpins. Serpins inhibit their cognate protease by an irreversible suicide mechanism starting with the attack… read more here.
Keywords: lethal serpinopathy; pathological mechanisms; serpin; neurodegeneration lethal ... See more keywords