Trps1 transcription factor represses phosphate-induced expression of SerpinB2 in osteogenic cells.
Sign Up to like & getrecommendations! Published in 2020 at "Bone"
DOI: 10.1016/j.bone.2020.115673
Abstract: Serine protease inhibitor SerpinB2 is one of the most upregulated proteins following cellular stress. This multifunctional serpin has been attributed a number of pleiotropic activities, including roles in cell survival, proliferation, differentiation, immunity and extracellular… read more here.
Keywords: cells producing; serpinb2; mineralized ecm; expression ... See more keywords
SERPINB2 overexpression inhibited cell proliferation, invasion and migration, led to G2/M arrest, and increased radiosensitivity in nasopharyngeal carcinoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rrz003
Abstract: Abstract The aim of this study was to evaluate the effect of SERPINB2 on cell proliferation, cell cycle, epithelial–mesenchymal transition (EMT), invasion, migration, and radiosensitivity in nasopharyngeal carcinoma cells. Both CNE2R and CNE2 cells were… read more here.
Keywords: invasion migration; serpinb2; cell; proliferation ... See more keywords
Unveiling a novel serpinB2/tripeptidyl peptidase II signaling axis during senescence.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.259513
Abstract: Tripeptidyl peptidase II (TPPII) degrades N-terminal tripeptides from proteins and peptides. Studies in both human and mice have shown that TPPII deficiency is linked to cellular immune-senescence, lifespan regulation, and the aging process. However, the… read more here.
Keywords: senescence; serpinb2; tripeptidyl peptidase; activity ... See more keywords
SerpinB2 Regulates Immune Response in Kidney Injury and Aging.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2019101085
Abstract: BACKGROUND Expression of SerpinB2, a regulator of inflammatory processes, has been described in the context of macrophage activation and cellular senescence. Given that mechanisms for these processes interact and can shape kidney disease, it seems… read more here.
Keywords: serpinb2; knockout mice; expression; injury ... See more keywords
Low expression of SerpinB2 is associated with reduced survival in lung adenocarcinomas
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.21456
Abstract: Lung cancer is a leading cause of cancer deaths worldwide and new biomarkers are of utmost importance. Studies have indicated that the anti-plasminogen activators SerpinB2 and Neuroserpin, and the adhesion molecule L1CAM, have a coordinated… read more here.
Keywords: serpinb2 associated; serpinb2; expression serpinb2; low expression ... See more keywords