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   Articles with "serpine1" as a keyword



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Identification of a novel circular RNA circZNF652/miR-486-5p/SERPINE1 signaling cascade that regulates cancer aggressiveness in glioblastoma (GBM)

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2021.2018096

Abstract: ABSTRACT Circular RNAs (circRNAs) are closely associated with cancer development in glioblastoma (GBM), and this study aims to explore the molecular mechanisms of a novel circular RNA circZNF652 in regulating GBM aggressiveness. The present study… read more here.

Keywords: serpine1; circular rna; circznf652; rna circznf652 ... See more keywords
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Oral application of a periodontal pathogen impacts SerpinE1 expression and pancreatic islet architecture in prediabetes

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recommendations! Published in 2017 at "Journal of Periodontal Research"

DOI: 10.1111/jre.12474

Abstract: BACKGROUND AND OBJECTIVES Epidemiological studies suggest a close association between periodontitis and prediabetes/insulin resistance (IR) but whether periodontitis causes prediabetes in humans is not known. Using various animal models, we have recently established that periodontitis… read more here.

Keywords: oral application; periodontal pathogen; serpine1; application periodontal ... See more keywords

Abstract LB303: Tumor microenvironment modulation by SERPINE1 increases radioimmunotherapy in murine model of gastric cancer

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-lb303

Abstract: The deposition of the extracellular matrix (ECM) is associated with poor prognosis and therapy response in gastric cancer. An elevated extracellular matrix (ECM) and interstitial fluid pressure in gastric cancer limits the targeting of HER2-expressing… read more here.

Keywords: 64cu trz; serpine1; gastric cancer; model ... See more keywords
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Serpine1 Regulates Peripheral Neutrophil Recruitment and Acts as Potential Target in Ischemic Stroke

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recommendations! Published in 2022 at "Journal of Inflammation Research"

DOI: 10.2147/jir.s361072

Abstract: Introduction Peripheral neutrophil infiltration can exacerbate ischemia–reperfusion injury. We focused on the relationship between various peripheral immune cells and cerebral ischemia–reperfusion (I/R) injury. Methods In this study, we investigated the effects of dauricine on neuronal… read more here.

Keywords: serpine1; peripheral neutrophil; injury; ischemia reperfusion ... See more keywords

A New Strategy to Identify ceRNA-Based CCDC144NL-AS1/SERPINE1 Regulatory Axis as a Novel Prognostic Biomarker for Stomach Adenocarcinoma via High Throughput Transcriptome Data Mining and Computational Verification

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recommendations! Published in 2021 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2021.802727

Abstract: Stomach adenocarcinoma (STAD) is one of the most malignant cancers that endanger human health. There is growing evidence that competitive endogenous RNA (ceRNA) regulatory networks play an important role in various human tumors. However, the… read more here.

Keywords: as1 serpine1; ccdc144nl as1; axis; serpine1 ... See more keywords

Secretory SERPINE1 Expression Is Increased by Antiplatelet Therapy, Inducing MMP1 Expression and Increasing Colon Cancer Metastasis

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23179596

Abstract: Contrary to many reports that antiplatelet agents inhibit cancer growth and metastasis, new solid tumors have been reported in patients receiving long-term antiplatelet therapy. We investigated the effects of these agents directly on cancer cells… read more here.

Keywords: serpine1; expression; antiplatelet therapy; antiplatelet ... See more keywords
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Knockdown of SERPINE1 reverses resistance of triple-negative breast cancer to paclitaxel via suppression of VEGFA

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recommendations! Published in 2020 at "Oncology Reports"

DOI: 10.3892/or.2020.7770

Abstract: Breast cancer (BC) has a poor prognosis and a high number of visceral metastases. Serine protease inhibitor, clade E member 1 (SERPINE1) is a molecule involved in several human malignancies. However, it remains unknown if… read more here.

Keywords: serpine1; knockdown serpine1; resistance; breast cancer ... See more keywords