LCRMP-1 induces tumor angiogenesis by transcriptionally upregulating SERPINE1 in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-09071-y
Abstract: Angiogenesis is a crucial process in cancer progression, particularly in malignant tumors, as it facilitates tumor growth and metastasis by generating new blood vessels that supply vital nutrients and oxygen. However, the regulatory mechanism governing… read more here.
Keywords: lung; lung adenocarcinoma; angiogenesis; serpine1 ... See more keywords
Identification of a novel circular RNA circZNF652/miR-486-5p/SERPINE1 signaling cascade that regulates cancer aggressiveness in glioblastoma (GBM)
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2018096
Abstract: ABSTRACT Circular RNAs (circRNAs) are closely associated with cancer development in glioblastoma (GBM), and this study aims to explore the molecular mechanisms of a novel circular RNA circZNF652 in regulating GBM aggressiveness. The present study… read more here.
Keywords: serpine1; circular rna; circznf652; rna circznf652 ... See more keywords
Pan‐cancer analysis of SERPINE1 with a concentration on immune therapeutic and prognostic in gastric cancer
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.18579
Abstract: The serine protease inhibitor clade E member 1 (SERPINE1) is a key modulator of the plasminogen/plasminase system and has been demonstrated to promote tumor progression and metastasis in various tumours. However, although much literature has… read more here.
Keywords: cancer; analysis; pan cancer; expression ... See more keywords
Oral application of a periodontal pathogen impacts SerpinE1 expression and pancreatic islet architecture in prediabetes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Periodontal Research"
DOI: 10.1111/jre.12474
Abstract: BACKGROUND AND OBJECTIVES Epidemiological studies suggest a close association between periodontitis and prediabetes/insulin resistance (IR) but whether periodontitis causes prediabetes in humans is not known. Using various animal models, we have recently established that periodontitis… read more here.
Keywords: oral application; periodontal pathogen; serpine1; application periodontal ... See more keywords
Abstract LB303: Tumor microenvironment modulation by SERPINE1 increases radioimmunotherapy in murine model of gastric cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb303
Abstract: The deposition of the extracellular matrix (ECM) is associated with poor prognosis and therapy response in gastric cancer. An elevated extracellular matrix (ECM) and interstitial fluid pressure in gastric cancer limits the targeting of HER2-expressing… read more here.
Keywords: 64cu trz; serpine1; gastric cancer; model ... See more keywords
BFGF mitigates CTX-induced ovarian cytotoxicity via SERPINE1/HIF-1 and Nrf-2/HO-1 signaling pathways
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Ovarian Research"
DOI: 10.1186/s13048-025-01736-w
Abstract: Chemotherapy-induced ovarian damage is a significant concern for female cancer patients, often resulting in infertility, hormonal imbalance, and premature ovarian failure. Cyclophosphamide (CTX), a widely used chemotherapeutic agent, is highly effective against tumors but causes… read more here.
Keywords: induced ovarian; serpine1 hif; ovarian cytotoxicity; ctx induced ... See more keywords
Serpine1 Regulates Peripheral Neutrophil Recruitment and Acts as Potential Target in Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s361072
Abstract: Introduction Peripheral neutrophil infiltration can exacerbate ischemia–reperfusion injury. We focused on the relationship between various peripheral immune cells and cerebral ischemia–reperfusion (I/R) injury. Methods In this study, we investigated the effects of dauricine on neuronal… read more here.
Keywords: serpine1; peripheral neutrophil; injury; ischemia reperfusion ... See more keywords
Transcriptional Induction of SERPINE1 and Fibrinolysis Inhibition as Predominant Effects of Glucocorticoids on the Cancer Coagulome
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DOI: 10.21873/anticanres.17145
Abstract: Background/Aim: How tumors regulate the genes of the coagulome is crucial for cancer-associated thrombosis and the occurrence of venous thromboembolic complications in patients with cancer. We have previously reported potent yet complex effects of glucocorticoids… read more here.
Keywords: cancer; fibrinolysis inhibition; serpine1; effects glucocorticoids ... See more keywords
A New Strategy to Identify ceRNA-Based CCDC144NL-AS1/SERPINE1 Regulatory Axis as a Novel Prognostic Biomarker for Stomach Adenocarcinoma via High Throughput Transcriptome Data Mining and Computational Verification
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.802727
Abstract: Stomach adenocarcinoma (STAD) is one of the most malignant cancers that endanger human health. There is growing evidence that competitive endogenous RNA (ceRNA) regulatory networks play an important role in various human tumors. However, the… read more here.
Keywords: as1 serpine1; ccdc144nl as1; axis; serpine1 ... See more keywords
Secretory SERPINE1 Expression Is Increased by Antiplatelet Therapy, Inducing MMP1 Expression and Increasing Colon Cancer Metastasis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179596
Abstract: Contrary to many reports that antiplatelet agents inhibit cancer growth and metastasis, new solid tumors have been reported in patients receiving long-term antiplatelet therapy. We investigated the effects of these agents directly on cancer cells… read more here.
Keywords: serpine1; expression; antiplatelet therapy; antiplatelet ... See more keywords
Knockdown of SERPINE1 reverses resistance of triple-negative breast cancer to paclitaxel via suppression of VEGFA
Sign Up to like & getrecommendations! Published in 2020 at "Oncology Reports"
DOI: 10.3892/or.2020.7770
Abstract: Breast cancer (BC) has a poor prognosis and a high number of visceral metastases. Serine protease inhibitor, clade E member 1 (SERPINE1) is a molecule involved in several human malignancies. However, it remains unknown if… read more here.
Keywords: serpine1; knockdown serpine1; resistance; breast cancer ... See more keywords