Colorectal carcinoma occurring via the adenoma–carcinoma pathway in patients with serrated polyposis syndrome
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DOI: 10.1007/s00535-022-01858-8
Abstract: Although serrated polyposis syndrome (SPS) is associated with an increased colorectal cancer (CRC) risk, the carcinogenic mechanisms remain unknown. We investigated clinicopathological characteristics and genetic abnormalities in colorectal polyps and CRC to elucidate carcinogenic mechanisms… read more here.
Keywords: serrated polyposis; carcinoma pathway; carcinoma; adenoma carcinoma ... See more keywords
High incidence of advanced colorectal neoplasia during endoscopic surveillance in serrated polyposis syndrome.
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DOI: 10.1055/a-0656-5557
Abstract: BACKGROUND Serrated polyposis syndrome (SPS) has been associated with an increased risk of colorectal cancer (CRC). Accordingly, intensive surveillance with annual colonoscopy is advised. The aim of this multicenter study was to describe the risk… read more here.
Keywords: incidence; surveillance; advanced neoplasia; endoscopic surveillance ... See more keywords
Appendiceal lesions in serrated polyposis patients are easily overlooked but only seldomly lead to colorectal cancer
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DOI: 10.1055/a-2025-0845
Abstract: BACKGROUND Serrated polyposis syndrome (SPS) is the most prevalent colonic polyposis syndrome and is associated with an increased colorectal cancer risk. A recent study in resected appendices of SPS patients reported that 6/23 (26.1 %) of… read more here.
Keywords: appendiceal lesions; appendiceal; colorectal cancer; serrated polyposis ... See more keywords
Serrated Polyposis Syndrome in a Young Adolescent Patient
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DOI: 10.1097/mpg.0000000000003546
Abstract: Serrated polyps are pathological neoplastic lesions in the colon with subtle gross morphology leading to underreporting during colonoscopy. While detection rates are increasing in average-risk adult screening colonoscopy, the rate of detection during pediatric colonoscopy… read more here.
Keywords: young adolescent; syndrome young; serrated polyposis; polyposis syndrome ... See more keywords
Germline variant testing in serrated polyposis syndrome
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DOI: 10.1111/jgh.15791
Abstract: Serrated polyposis syndrome (SPS) is now known to be the commonest polyposis syndrome. Previous analyses for germline variants have shown no consistent positive findings. To exclude other polyposis syndromes, 2019 British Society of Gastroenterology (BSG)… read more here.
Keywords: germline variant; gastroenterology; serrated polyposis; polyposis ... See more keywords
Serrated polyposis syndrome may go undiagnosed even in structured colorectal cancer screening programmes performed by endoscopists with otherwise good quality indices
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DOI: 10.1136/gutjnl-2017-315321
Abstract: We have read the article by Ijspeert et al with great interest as it comprises the largest series of colonoscopies concerning the serrated polyposis syndrome (SPS) published so far.1 SPS is characterised by multiple serrated… read more here.
Keywords: serrated polyposis; colorectal cancer; polyposis syndrome;
Germline mutations in WNK2 could be associated with serrated polyposis syndrome
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DOI: 10.1136/jmg-2022-108684
Abstract: Background Patients with serrated polyposis syndrome (SPS) have multiple and/or large serrated colonic polyps and higher risk for colorectal cancer. SPS inherited genetic basis is mostly unknown. We aimed to identify new germline predisposition factors… read more here.
Keywords: sps cases; germline; serrated polyposis; gene ... See more keywords
Unraveling the impact of a germline heterozygous POLD1 frameshift variant in serrated polyposis syndrome
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DOI: 10.3389/fmolb.2023.1119900
Abstract: Serrated polyposis syndrome (SPS) is one of the most frequent polyposis syndromes characterized by an increased risk for developing colorectal cancer (CRC). Although SPS etiology has been mainly associated with environmental factors, germline predisposition to… read more here.
Keywords: frameshift; pold1; serrated polyposis; frameshift variant ... See more keywords