Involvement of protein kinase C beta1-serotonin transporter system dysfunction in emotional behaviors in stressed mice
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2020.104826
Abstract: Selective serotonin reuptake inhibitors are the first-line antidepressants for treating major depressive and post-traumatic stress disorders. These inhibitors directly bind to the serotonin transporter (SERT). Protein kinase C (PKC) is a key regulator of SERT… read more here.
Keywords: serotonin transporter; sert; stressed mice; stress ... See more keywords
Human Serotonin Transporter Coding Variation Establishes Conformational Bias with Functional Consequences.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00689
Abstract: The antidepressant-sensitive serotonin (5-HT) transporter (SERT) dictates rapid, high-affinity clearance of the neurotransmitter in both the brain and periphery. In a study of families with multiple individuals diagnosed with autism spectrum disorder (ASD), we previously… read more here.
Keywords: serotonin transporter; human serotonin; sert; coding variation ... See more keywords
The SERT Met172 Mouse: An Engineered Model To Elucidate the Contributions of Serotonin Signaling to Cocaine Action.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00005
Abstract: Cocaine abuse and addiction remain highly prevalent and, unfortunately, poorly treated. It is well-known that essential aspects of cocaine's addictive actions involve the drug's ability to block the presynaptic dopamine (DA) transporter (DAT), thereby elevating… read more here.
Keywords: sert; sert met172; model; cocaine ... See more keywords
Assessment of fear and anxiety associated behaviors, physiology and neural circuits in rats with reduced serotonin transporter (SERT) levels
Sign Up to like & getrecommendations! Published in 2019 at "Translational Psychiatry"
DOI: 10.1038/s41398-019-0368-y
Abstract: Genetic variation in serotonin transporter (SERT) that reduces transcriptional efficiency is associated with higher anxiety and fear traits and a greater incidence of post traumatic stress disorder (PTSD). Although previous studies have shown that rats… read more here.
Keywords: serotonin transporter; anxiety; fear; sert ... See more keywords
Molecular and functional characterization of the Gulf toadfish serotonin transporter SLC6A4
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Experimental Biology"
DOI: 10.1242/jeb.170928
Abstract: ABSTRACT The serotonin transporter (SERT) functions in the uptake of the neurotransmitter serotonin (5-HT) from the extracellular milieu and is the molecular target of the selective serotonin re-uptake inhibitors (SSRIs), a common group of anti-depressants.… read more here.
Keywords: serotonin transporter; sert; serotonin; transporter ... See more keywords
SAHA Alleviates Diarrhea-Predominant Irritable Bowel Syndrome Through Regulation of the p-STAT3/SERT/5-HT Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s331303
Abstract: Objective Irritable bowel syndrome (IBS) is characterized by abdominal pain, bloating, and stool irregularity. However, its pathophysiological mechanisms, which trigger intestinal motility disorders and diarrhea leading to diarrhea-predominant IBS (D-IBS), remain largely unknown. Methods In… read more here.
Keywords: stat3; stat3 sert; model; signaling pathway ... See more keywords
A mechanism of uncompetitive inhibition of the serotonin transporter
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.82641
Abstract: The serotonin transporter (SERT/SLC6A4) is arguably the most extensively studied solute carrier (SLC). During its eponymous action - i.e., the retrieval of serotonin from the extracellular space - SERT undergoes a conformational cycle. Typical inhibitors… read more here.
Keywords: inhibition serotonin; inhibition; sert; ecsi ... See more keywords