Serum Neurofilament Light and Multiple Sclerosis Progression Independent of Acute Inflammation
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.47588
Abstract: This cohort study investigates serum neurofilament light concentration as a biomarker associated with disability progression in multiple sclerosis in the absence of acute inflammation. read more here.
Keywords: neurofilament light; progression; acute inflammation; multiple sclerosis ... See more keywords
Comparison of SimoaTM and EllaTM to assess serum neurofilament‐light chain in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51355
Abstract: We compared SimoaTM and EllaTM immunoassays to assess serum neurofilament‐light chain levels in 203 multiple sclerosis patients from the OFSEP HD study. There was a strong correlation (ρ = 0.86, p < 0.0001) between both… read more here.
Keywords: serum neurofilament; neurofilament light; multiple sclerosis; light chain ... See more keywords
Characteristics of serum neurofilament light chain as a biomarker in hereditary spastic paraplegia type 4
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51518
Abstract: While the anticipated rise of disease‐modifying therapies calls for reliable trial outcome parameters, fluid biomarkers are lacking in spastic paraplegia type 4 (SPG4), the most prevalent form of hereditary spastic paraplegia. We therefore investigated serum… read more here.
Keywords: spastic paraplegia; neurofilament light; paraplegia; hereditary spastic ... See more keywords
Vitamin D supplementation and serum neurofilament light chain in interferon‐beta‐1b‐treated MS patients
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1772
Abstract: Serum neurofilament light chain (sNfL) is a promising biomarker of MS activity, progression, and treatment response. The aim of the present study was to address whether sNfL concentrations are affected by supplementation of vitamin D… read more here.
Keywords: interferon beta; serum neurofilament; neurofilament light; light chain ... See more keywords
Changes in serum neurofilament light chain levels following narrowband ultraviolet B phototherapy in clinically isolated syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2494
Abstract: To determine whether serum neurofilament light chain (sNfL) levels are suppressed in patients with the clinically isolated syndrome (CIS) following narrowband ultraviolet B phototherapy (UVB‐PT). read more here.
Keywords: light chain; serum neurofilament; clinically isolated; isolated syndrome ... See more keywords
Serum Neurofilament Light and Clinical Biomarkers for Disease Staging in Huntington's Disease
Sign Up to like & getrecommendations! Published in 2024 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13993
Abstract: Recently, the Huntington ’ s Disease (HD) Integrated Staging System (HD-ISS) was developed as a new framework to standardize clinical research for HD. 1 Nevertheless, HD patients can show variable performance in certain tests at… read more here.
Keywords: disease; clinical biomarkers; neurofilament light; huntington disease ... See more keywords
Serum Neurofilament Light Chain in Wilson's Disease: A Promising Indicator but Unparallel to Real‐Time Treatment Response
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.29039
Abstract: Wilson's disease (WD) currently lacks a promising indicator that could reflect neurological impairment and monitor treatment outcome. We aimed to investigate whether serum neurofilament light chain (sNfL) functions as a candidate for disease assessment and… read more here.
Keywords: promising indicator; neurofilament light; wilson disease; treatment ... See more keywords
Serum neurofilament light chain (sNfL) values in a large cross-sectional population of children with asymptomatic to moderate COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurology"
DOI: 10.1007/s00415-021-10554-1
Abstract: Serum neurofilament light chain (sNfL) is an established biomarker of neuro-axonal damage in multiple neurological disorders. Raised sNfL levels have been reported in adults infected with pandemic coronavirus disease 2019 (COVID-19). Levels in children infected… read more here.
Keywords: antibody; moderate covid; covid; asymptomatic moderate ... See more keywords
The role of serum neurofilament light (sNfL) as a biomarker in multiple sclerosis: insights from a systematic review
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neurology"
DOI: 10.1007/s00415-025-13093-1
Abstract: This systematic literature review (SLR) was conducted to explore the role of serum neurofilament light chain (sNfL) as a biomarker in multiple sclerosis (MS) disease management. The review was conducted in accordance with the recommendation… read more here.
Keywords: review; neurofilament light; role serum; serum neurofilament ... See more keywords
Serum neurofilament light chain as a severity marker for spinocerebellar ataxia
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92855-z
Abstract: Since the serum neurofilament light (NfL) chain is known as a promising biomarker in neurodegenerative diseases, we aimed to evaluate serum NfL as a biomarker indicating neuronal damage in autosomal-dominant (AD) spinocerebellar ataxia (SCA). We… read more here.
Keywords: neurofilament light; ataxia; value; serum ... See more keywords
Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-05117-x
Abstract: Deep brain stimulation (DBS) is a potent symptomatic therapy for Parkinson’s disease, but it is debated whether it causes or prevents neurodegeneration. We used serum neurofilament light chain (NFL) as a reporter for neuronal damage… read more here.
Keywords: dbs surgery; serum neurofilament; neuronal damage; stimulation ... See more keywords