Serum neurofilaments as candidate biomarkers of natalizumab associated progressive multifocal leukoencephalopathy
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25523
Abstract: We read with great interest the article published by Dalla Costa et al concerning the role of serum neurofilament light chains (NfL) as candidate biomarkers of progressive multifocal leukoencephalopathy (PML) during natalizumab treatment (NTZ-PML) in… read more here.
Keywords: nfl levels; pml onset; serum; serum nfl ... See more keywords
Serum neurofilament light chain and postural instability/gait difficulty (PIGD) subtypes of Parkinson’s disease in the MARK-PD study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-022-02464-x
Abstract: The PIGD (postural instability / gait difficulty) subtype of Parkinson´s disease (PD) is associated with faster cognitive and motor decline. So far, there are no quantifiable biomarkers to aid clinical subtyping. Neurofilament light chain (NfL)… read more here.
Keywords: serum nfl; postural instability; instability gait; parkinson disease ... See more keywords
Serum neurofilament light chain as a severity marker for spinocerebellar ataxia
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DOI: 10.1038/s41598-021-92855-z
Abstract: Since the serum neurofilament light (NfL) chain is known as a promising biomarker in neurodegenerative diseases, we aimed to evaluate serum NfL as a biomarker indicating neuronal damage in autosomal-dominant (AD) spinocerebellar ataxia (SCA). We… read more here.
Keywords: neurofilament light; ataxia; value; serum ... See more keywords
Association between serum NfL and GFAP levels and head impact burden in women's collegiate water polo.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurotrauma"
DOI: 10.1089/neu.2022.0300
Abstract: Recent investigations have identified water polo athletes as at risk for concussions and repetitive subconcussive head impacts. However, head impact exposure in collegiate varsity women's water polo has not yet been longitudinally quantified. We aimed… read more here.
Keywords: water polo; head impact; serum nfl;
Serum neurofilament light chain as a surrogate of cognitive decline in sporadic and familial Frontotemporal dementia.
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DOI: 10.1111/ene.15058
Abstract: BACKGROUND Neurofilament light chain (NfL) has recently been proposed as a promising biomarker in Frontotemporal Dementia (FTD). We investigated the correlation of both cerebrospinal fluid (CSF) and serum NfL with detailed neuropsychological data and cognitive… read more here.
Keywords: neurofilament light; serum; csf serum; serum nfl ... See more keywords
The relationship between serum neurofilament light chain and glial fibrillary acidic protein with the REM sleep behavior disorder subtype of Parkinson's disease
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15780
Abstract: Studies have shown that rapid eye movement (REM) sleep behavior disorder (RBD) is a subtype of Parkinson's disease (PD) characterized by severe cognitive impairment and rapid disease progression. However, reliable biological markers are lacking presently.… read more here.
Keywords: sleep behavior; nfl gfap; disease; rem sleep ... See more keywords
Evaluation of neurofilament light chain in the cerebrospinal fluid and blood as a biomarker for neuronal damage in experimental pneumococcal meningitis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01966-3
Abstract: Background Pneumococcal meningitis (PM) remains a global public health concern and affects all age groups. If acquired during infancy or childhood, permanent neurofunctional deficits including cognitive impairment, cerebral palsy, and secondary epilepsy are typical sequelae… read more here.
Keywords: csf; blood; serum nfl; pneumococcal meningitis ... See more keywords
Prognostic value of serum neurofilaments in patients with clinically isolated syndromes
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DOI: 10.1212/wnl.0000000000006902
Abstract: Objective To assess the prognostic role of serum neurofilament light chains (NfL) for clinically defined multiple sclerosis (CDMS) and McDonald 2017 multiple sclerosis (MS) in patients with clinically isolated syndromes (CIS). Methods We retrospectively analyzed… read more here.
Keywords: prognostic value; serum nfl; serum; clinically isolated ... See more keywords
Validation of serum neurofilaments as prognostic and potential pharmacodynamic biomarkers for ALS
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DOI: 10.1212/wnl.0000000000009559
Abstract: Objective To identify preferred neurofilament assays and clinically validate serum neurofilament light (NfL) and phosphorylated neurofilament heavy (pNfH) as prognostic and potential pharmacodynamic biomarkers relevant to amyotrophic lateral sclerosis (ALS) therapy development. Methods In this… read more here.
Keywords: serum nfl; serum; pnfh; prognostic potential ... See more keywords
Neurofilament light as a biomarker in traumatic brain injury
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DOI: 10.1212/wnl.0000000000009983
Abstract: Objective To determine whether serum neurofilament light (NfL) correlates with CSF NfL, traumatic brain injury (TBI) diagnosis, injury severity, brain volume, and diffusion tensor imaging (DTI) estimates of traumatic axonal injury (TAI). Methods Participants were… read more here.
Keywords: serum nfl; traumatic brain; brain injury; injury ... See more keywords
Predictive Value of Serum Neurofilament Light Chain Levels in Anti-NMDA Receptor Encephalitis
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DOI: 10.1212/wnl.0000000000207221
Abstract: Background and Objectives Determinants of disease activity and prognosis are limited in anti-NMDA receptor (NMDAR) encephalitis. Neurofilament light chains (NfL) are markers of axonal damage and have been identified as valuable biomarkers for neurodegenerative and… read more here.
Keywords: disease; nfl; encephalitis; nfl levels ... See more keywords