Serum-Stable and Selective Backbone-N-Methylated Cyclic Peptides That Inhibit Prokaryotic Glycolytic Mutases.
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DOI: 10.1021/acschembio.2c00403
Abstract: N-Methylated amino acids (N-MeAAs) are privileged residues of naturally occurring peptides critical to bioactivity. However, de novo discovery from ribosome display is limited by poor incorporation of N-methylated amino acids into the nascent peptide chain… read more here.
Keywords: metal ion; backbone methylated; methylated cyclic; selective backbone ... See more keywords