Efficacy of febuxostat versus allopurinol and the predictors of achieving target serum urate in a cohort of Thai people with gout
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DOI: 10.1007/s10067-020-05262-6
Abstract: Objective The objectives of our study were to compare the efficacy of febuxostat with allopurinol in Thai subjects with gout, as well as to determine the predictive factors of responsiveness to urate-lowering agents and to… read more here.
Keywords: serum urate; target; efficacy; achieving target ... See more keywords
Changes in Serum Urate Levels after Bariatric Surgery in Patients with Obesity: An Observational Study
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DOI: 10.1007/s11695-024-07191-8
Abstract: Obesity is a risk factor for hyperuricemia and gout, while weight reduction can reduce urate levels. The aim of this study was to examine the effect of bariatric surgery on longitudinal serum urate levels. We… read more here.
Keywords: serum urate; observational study; urate levels; bariatric surgery ... See more keywords
Different associations between serum urate and diabetic complications in men and postmenopausal women.
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2020.108005
Abstract: AIMS The objective of this study was to investigate the different associations of the serum urate (SUA) level with cardiovascular and cerebrovascular diseases (CVD), diabetic kidney disease (DKD) and diabetic retinopathy (DR) in Chinese adults.… read more here.
Keywords: serum urate; associations serum; different associations; sua level ... See more keywords
An association of smoking with serum urate and gout: A health paradox.
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in arthritis and rheumatism"
DOI: 10.1016/j.semarthrit.2017.11.004
Abstract: BACKGROUND The potential effect of cigarette smoking on levels of serum urate and risk of gout has been considered by a large number of studies, either as the primary variable of interest or as a… read more here.
Keywords: serum urate; smoking serum; gout; risk gout ... See more keywords
Evaluation of the causal effects of blood lipid levels on gout with summary level GWAS data: two-sample Mendelian randomization and mediation analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of human genetics"
DOI: 10.1038/s10038-020-00863-0
Abstract: Observational studies have identified gout patients are often comorbid with dyslipidemia. However, the relationship between dyslipidemia and gout is still unclear. We first performed Mendelian randomization (MR) to evaluate the causal effect of four lipid… read more here.
Keywords: mendelian randomization; mediation analysis; gout; serum urate ... See more keywords
Large-scale cross-ancestry genome-wide meta-analysis of serum urate
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DOI: 10.1038/s41467-024-47805-4
Abstract: Hyperuricemia is an essential causal risk factor for gout and is associated with cardiometabolic diseases. Given the limited contribution of East Asian ancestry to genome-wide association studies of serum urate, the genetic architecture of serum… read more here.
Keywords: serum; genome wide; analysis; serum urate ... See more keywords
The polymorphism rs35767 at IGF1 locus is associated with serum urate levels
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DOI: 10.1038/s41598-018-29665-3
Abstract: Previous studies suggested that the IGF-1/IGF-1 receptor signaling pathway may contribute to regulate uric acid levels. To confirm this hypothesis, we assessed the effects of the IGF-1-raising genetic variant rs35767 on urate levels in serum… read more here.
Keywords: serum urate; uric acid; urate levels; polymorphism rs35767 ... See more keywords
Genetically predicted serum urate and cancer risk: A Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2025 at "Scandinavian journal of rheumatology"
DOI: 10.1080/03009742.2025.2512667
Abstract: Objective To evaluate the causal effect of genetically predicted serum urate (SU) levels on the risk of overall and major site-specific cancers in individuals of European ancestry, using Mendelian randomization (MR) analysis. Method Data from… read more here.
Keywords: cancer; study; risk; serum urate ... See more keywords
Serum Urate and Heart Failure: A Bidirectional Mendelian Randomisation Study.
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DOI: 10.1093/eurjpc/zwac100
Abstract: AIMS Observational studies indicate that serum urate level is associated with heart failure. However, whether this association is causal remains controversial, due to confounding factors and reverse causality. We aim to evaluate the causal relationship… read more here.
Keywords: heart failure; serum urate; study;
Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control.
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DOI: 10.1093/hmg/ddaa013
Abstract: High serum urate is a prerequisite for gout and associated with metabolic disease. Genome-wide association studies (GWAS) have reported dozens of loci associated with serum urate control, however there has been little progress in understanding… read more here.
Keywords: serum urate; associated loci; urate control; serum ... See more keywords
#2706 Genetically determined reduction of renal carbonic anhydrase 12 is associated with decreased kidney function and increased serum urate
Sign Up to like & getrecommendations! Published in 2025 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaf116.002
Abstract: Chronic Kidney Disease (CKD) affects 10% of the world's population and is the third fastest growing cause of death globally. Hyperuricemia and gout are frequent comorbidities of CKD and are associated with worse prognosis and… read more here.
Keywords: increased serum; function; kidney function; serum urate ... See more keywords