Efficacy of febuxostat versus allopurinol and the predictors of achieving target serum urate in a cohort of Thai people with gout
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DOI: 10.1007/s10067-020-05262-6
Abstract: Objective The objectives of our study were to compare the efficacy of febuxostat with allopurinol in Thai subjects with gout, as well as to determine the predictive factors of responsiveness to urate-lowering agents and to… read more here.
Keywords: serum urate; target; efficacy; achieving target ... See more keywords
Different associations between serum urate and diabetic complications in men and postmenopausal women.
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2020.108005
Abstract: AIMS The objective of this study was to investigate the different associations of the serum urate (SUA) level with cardiovascular and cerebrovascular diseases (CVD), diabetic kidney disease (DKD) and diabetic retinopathy (DR) in Chinese adults.… read more here.
Keywords: serum urate; associations serum; different associations; sua level ... See more keywords
An association of smoking with serum urate and gout: A health paradox.
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in arthritis and rheumatism"
DOI: 10.1016/j.semarthrit.2017.11.004
Abstract: BACKGROUND The potential effect of cigarette smoking on levels of serum urate and risk of gout has been considered by a large number of studies, either as the primary variable of interest or as a… read more here.
Keywords: serum urate; smoking serum; gout; risk gout ... See more keywords
Evaluation of the causal effects of blood lipid levels on gout with summary level GWAS data: two-sample Mendelian randomization and mediation analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of human genetics"
DOI: 10.1038/s10038-020-00863-0
Abstract: Observational studies have identified gout patients are often comorbid with dyslipidemia. However, the relationship between dyslipidemia and gout is still unclear. We first performed Mendelian randomization (MR) to evaluate the causal effect of four lipid… read more here.
Keywords: mendelian randomization; mediation analysis; gout; serum urate ... See more keywords
The polymorphism rs35767 at IGF1 locus is associated with serum urate levels
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DOI: 10.1038/s41598-018-29665-3
Abstract: Previous studies suggested that the IGF-1/IGF-1 receptor signaling pathway may contribute to regulate uric acid levels. To confirm this hypothesis, we assessed the effects of the IGF-1-raising genetic variant rs35767 on urate levels in serum… read more here.
Keywords: serum urate; uric acid; urate levels; polymorphism rs35767 ... See more keywords
Serum Urate and Heart Failure: A Bidirectional Mendelian Randomisation Study.
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DOI: 10.1093/eurjpc/zwac100
Abstract: AIMS Observational studies indicate that serum urate level is associated with heart failure. However, whether this association is causal remains controversial, due to confounding factors and reverse causality. We aim to evaluate the causal relationship… read more here.
Keywords: heart failure; serum urate; study;
Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control.
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DOI: 10.1093/hmg/ddaa013
Abstract: High serum urate is a prerequisite for gout and associated with metabolic disease. Genome-wide association studies (GWAS) have reported dozens of loci associated with serum urate control, however there has been little progress in understanding… read more here.
Keywords: serum urate; associated loci; urate control; serum ... See more keywords
Using human genetics to understand the epidemiological association between obesity, serum urate and gout.
Sign Up to like & getrecommendations! Published in 2023 at "Rheumatology"
DOI: 10.1093/rheumatology/kead054
Abstract: OBJECTIVES We aim to clarify the genetic overlaps underlying obesity-related traits, serum urate, and gout. METHODS We conducted a comprehensive genome-wide cross-trait analysis to identify genetic correlation, pleiotropic loci and causal relationship between obesity (exposures),… read more here.
Keywords: gout; obesity; serum urate; association ... See more keywords
[PP.30.27] A GENOME-WIDE ASSOCIATION STUDY ON THE EFFECT OF HYDROCHLOROTHIAZIDE ON SERUM URATE CONCENTRATION
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DOI: 10.1097/01.hjh.0000523997.14081.cf
Abstract: Objective: Increase in serum urate concentration and development of gout are common side effects of thiazide diuretics. The aim of this study was to recognize genetic associations of hydrochlorothiazide (HCTZ) -induced change in serum urate… read more here.
Keywords: serum urate; hctz induced; study; urate concentration ... See more keywords
Chasing crystals out of the body: will treat to serum urate target for gout help us get there?
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2016-210436
Abstract: In this issue of the journal, Kiltz et al published the treat-to-target (T2T) recommendations for gout,1 based on a systematic literature review (SLR) using standard methodology based on Oxford Center for Evidence-based Medicine system and… read more here.
Keywords: t2t recommendations; serum urate; treat; target ... See more keywords
Allopurinol dose escalation to achieve serum urate below 6 mg/dL: an open-label extension study
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DOI: 10.1136/annrheumdis-2017-211873
Abstract: Objectives To determine the long-term safety and efficacy of allopurinol dose escalation (DE) to achieve target serum urate (SU) in gout. Methods People, including those with chronic kidney disease, who completed the first 12 months of… read more here.
Keywords: serum urate; allopurinol dose; dose escalation; extension study ... See more keywords