d‐amino acid modification protects N‐Acetyl‐seryl‐aspartyl‐lysyl‐proline from physiological hydroxylation and increases its antifibrotic effects on hepatic fibrosis
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DOI: 10.1002/iub.2037
Abstract: N‐Acetyl‐seryl‐aspartyl‐lysyl‐proline (Ac‐SDKP) is a critical negative regulator of fibrosis development in the liver. However, its extremely short half‐life in vivo greatly compromises its potential applications. Here, we report an Ac‐SDKP analog peptide with d‐amino acid… read more here.
Keywords: acetyl seryl; seryl aspartyl; amino acid; fibrosis ... See more keywords