Sesamin suppresses NSCLC cell proliferation and induces apoptosis via Akt/p53 pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2019.114848
Abstract: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer with a disappointing prognosis. The aim of this study was to investigate the anticancer effect of sesamin and the underlying mechanism. The… read more here.
Keywords: cell proliferation; sesamin; proliferation; p53 ... See more keywords
Sesamin Alleviates Asthma Airway Inflammation by Regulating Mitophagy and Mitochondrial Apoptosis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c07877
Abstract: Bronchial asthma poses a considerable burden on both individual patients and public health. Sesamin is a natural lignan that relieves asthma. However, the potential regulatory mechanism has not been fully validated. In this study, we… read more here.
Keywords: apoptosis; asthma airway; mitophagy mitochondrial; sesamin ... See more keywords
Sesamin Activates Skeletal Muscle FNDC5 Expression and Increases Irisin Secretion via the SIRT1 Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c02794
Abstract: Sesamin, a major lignin mainly found in sesame (Sesamum indicum) oil and sesame seeds, has been demonstrated to possess lipoclasis-promoting, antiobesity, and antidiabetic effects. Irisin is a newly discovered myokine that has attracted great interest… read more here.
Keywords: irisin; sesamin; fndc5 expression; expression ... See more keywords
Supplementation of Sesamin Alleviates Stress-Induced Behavioral and Psychological Disorders via Reshaping the Gut Microbiota Structure.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b03652
Abstract: Sesamin, a lignan from sesame seed, has been reported to attenuate chronic mild stress-induced depressive-like behaviors. Gut microbiota play pivotal roles in mediating psychological behaviors by regulating gut barrier integrity and systemic inflammatory responses. Here,… read more here.
Keywords: behavioral psychological; sesamin; stress induced; psychological disorders ... See more keywords
Sesamin Protects Against Cardiac Remodeling Via Sirt3/ROS Pathway
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000486026
Abstract: Background/Aims: Cardiac remodeling is associated with oxidative stress. Sesamin, a well-known antioxidant from sesamin seeds, have been used extensively as traditional health foods. However, there is little known about the effect of sesamin on cardiac… read more here.
Keywords: ros pathway; sirt3 ros; sesamin; via sirt3 ... See more keywords
Sesamin suppresses aging phenotypes in adult muscular and nervous systems and intestines in a Drosophila senescence-accelerated model.
Sign Up to like & getrecommendations! Published in 2019 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201902_17146
Abstract: OBJECTIVE Sesamin is a major lignan constituent of sesame and possesses various health-promoting effects. Previous studies have demonstrated that sesamin extends the lifespan of Drosophila and Caenorhabditis elegans and corrects oxidative damage-related tissue dysfunction in mammals. To understand… read more here.
Keywords: senescence accelerated; sesamin; aging effects; drosophila senescence ... See more keywords
Sesamin Exerts an Antioxidative Effect by Activating the Nrf2 Transcription Factor in the Glial Cells of the Central Nervous System in Drosophila Larvae
Sign Up to like & getrecommendations! Published in 2024 at "Antioxidants"
DOI: 10.3390/antiox13070787
Abstract: Sesame seeds are abundant in sesamin, which exerts health-promoting effects such as extending the lifespan of adult Drosophila and suppressing oxidative stress by activating the Nrf2 transcription factor. Here, we investigated whether sesamin activated Nrf2… read more here.
Keywords: activating nrf2; sesamin; transcription factor; sesamin exerts ... See more keywords
Protective Effects of Sesamin against UVB-Induced Skin Inflammation and Photodamage In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2019 at "Biomolecules"
DOI: 10.3390/biom9090479
Abstract: Ultraviolet (UV) exposure has been demonstrated as the most critical factor causing extrinsic skin aging and inflammation. This study explored the protective effects and mechanisms of sesamin against skin photodamage. Sesamin reduced intracellular reactive oxygen… read more here.
Keywords: photodamage; sesamin; inflammation; skin ... See more keywords
Sesamin Induces MCL-1-Dependent Apoptosis in Activated T Cells and Ameliorates Experimental Atopic Dermatitis
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.116753
Abstract: Sesamin, a natural lignan derived from Sesamum indicum, has been reported to possess anti-inflammatory and pro-apoptotic properties. However, its effect on T cell-mediated diseases and the underlying molecular mechanisms remain unclear. In this study, we… read more here.
Keywords: sesamin; mcl dependent; activated cells; apoptosis activated ... See more keywords