Sestrin2 Regulates Mitochondrial Function and Autophagy via Nrf2/SIRT3 Signaling to Ameliorate Hypoxia/Reoxygenation‐Induced Rat's Cardiomyocyte Injury
Sign Up to like & getrecommendations! Published in 2025 at "Drug Development Research"
DOI: 10.1002/ddr.70150
Abstract: Mitigating myocardial ischemia‐reperfusion (I/R) injury poses a significant challenge, necessitating the exploration of novel therapeutic targets. Sestrin2 (Sesn2), a stress‐induced protein, has emerged as a potential candidate for attenuating I/R injury, yet its precise mechanisms… read more here.
Keywords: mitochondrial function; sirt3 signaling; nrf2 sirt3; injury ... See more keywords
Sestrin2 maintains OXPHOS integrity to modulate cardiac substrate metabolism during ischemia and reperfusion
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101824
Abstract: Sestrin2 (Sesn2) is a stress-inducible protein that declines with aging in the heart. We reported that rescue Sesn2 levels in aged mouse hearts through gene therapy improves the resistance of aged hearts to ischemia and… read more here.
Keywords: ischemia reperfusion; integrity; stress; sesn2 ... See more keywords
Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2.
Sign Up to like & getrecommendations! Published in 2022 at "Redox biology"
DOI: 10.1016/j.redox.2022.102310
Abstract: Although it is known that the expression and activity of sirtuin 1 (SIRT1) significantly decrease in doxorubicin (DOX)-induced cardiomyopathy, the role of interaction between SIRT1 and sestrin 2 (SESN2) is largely unknown. In this study,… read more here.
Keywords: sirt1; dox induced; induced cardiotoxicity; dox ... See more keywords
SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation
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DOI: 10.1038/s41598-017-19102-2
Abstract: Mitophagy, the selective degradation of mitochondria by autophagy, is crucial for the maintenance of healthy mitochondrial pool in cells. The critical event in mitophagy is the translocation of cytosolic Parkin, a ubiquitin ligase, to the… read more here.
Keywords: parkin translocation; mitochondrial translocation; translocation; sesn2 ... See more keywords
Direct scavenging of ROS by S-PPE NP reduces oxidative stress-induced stimulation of the SESN2/AMPK/KIM-1 pathway in acute kidney injury
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DOI: 10.1080/0886022x.2025.2509802
Abstract: Abstract Background Previous research demonstrated that treatment of acute kidney injury (AKI) with the antioxidant S-PPE NP reduced the levels of the oxidative stress-responsive protein Sestrin2 (SESN2), and suggested that kidney injury molecule 1 (KIM-1)… read more here.
Keywords: ppe; injury; kim; kidney injury ... See more keywords
SREBF1-mediated SND1 transcriptional activation promotes prostate cancer progression via MTDH interaction through the SESN2/AMPK/mTOR axis
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DOI: 10.1186/s12967-025-06762-2
Abstract: Prostate cancer (PCa) is a prevalent cancer and a major cause of cancer-related deaths in men worldwide. Growing evidence indicates that Staphylococcal nuclease and Tudor domain containing 1 (SND1) is a multifunctional protein extensively involved… read more here.
Keywords: ampk mtor; cancer; snd1; rna ... See more keywords
Sestrin2 aggravates oxidative stress of neurons by decreasing the expression of Nrf2.
Sign Up to like & getrecommendations! Published in 2018 at "European Review for Medical and Pharmacological Sciences"
DOI: 10.26355/eurrev_201806_15176
Abstract: Oxidative injury is an essential part of the pathological changes of cerebral ischemia-reperfusion. Sestrin2 (Sesn2), a conserved antioxidant protein, is activated under stress to protect cells against oxidative stress. This study mainly explored the function… read more here.
Keywords: cerebral ischemia; model; sesn2; ischemia reperfusion ... See more keywords
Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc−/GPX4 pathway
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2024.1504114
Abstract: Introduction Cerebral ischemia–reperfusion (IR) causes severe secondary brain injury. Previous studies have demonstrated that ferroptosis is involved in IR-induced brain injury. However, whether IR induces ferroptosis in brain microvascular endothelial cells (BMVECs) is not fully… read more here.
Keywords: gpx4 pathway; analysis; system gpx4; ferroptosis ... See more keywords
Docosahexaenoic Acid Enhances Oxaliplatin-Induced Autophagic Cell Death via the ER Stress/Sesn2 Pathway in Colorectal Cancer
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DOI: 10.3390/cancers11070982
Abstract: Oxaliplatin is an anticancer drug administered to colorectal cancer (CRC) patients in combination with 5-fluorouracil and antibodies (bevacizumab and cetuximab), thereby significantly improving the survival rate of CRC. However, due to various side effects associated… read more here.
Keywords: oxaliplatin induced; colorectal cancer; stress; dha ... See more keywords
Sestrin2 Suppression Promotes Endothelial–Mesenchymal Transition and Exacerbates Methylglyoxal-Induced Endothelial Dysfunction
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms252413463
Abstract: Sestrin2 (SESN2) is a stress-inducible protein known for its cytoprotective functions, but its role in diabetic vascular complications remains unclear. This study investigated the impact of SESN2 on methylglyoxal (MGO)-induced endothelial–mesenchymal transition (EndMT). Human endothelial… read more here.
Keywords: mesenchymal transition; induced endothelial; endothelial dysfunction; sesn2 ... See more keywords
Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.70211
Abstract: Mitochondrial unfold protein response (UPRmt) can induce mitophagy to protect cell from unfold protein. However, how UPRmt induces mitophagy to protect cell is not yet clear. Herein, Sesn2 was considered to be a key molecule… read more here.
Keywords: degeneration; protein response; sesn2; intervertebral disc ... See more keywords