Sestrin2 maintains OXPHOS integrity to modulate cardiac substrate metabolism during ischemia and reperfusion
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101824
Abstract: Sestrin2 (Sesn2) is a stress-inducible protein that declines with aging in the heart. We reported that rescue Sesn2 levels in aged mouse hearts through gene therapy improves the resistance of aged hearts to ischemia and… read more here.
Keywords: ischemia reperfusion; integrity; stress; sesn2 ... See more keywords
Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2.
Sign Up to like & getrecommendations! Published in 2022 at "Redox biology"
DOI: 10.1016/j.redox.2022.102310
Abstract: Although it is known that the expression and activity of sirtuin 1 (SIRT1) significantly decrease in doxorubicin (DOX)-induced cardiomyopathy, the role of interaction between SIRT1 and sestrin 2 (SESN2) is largely unknown. In this study,… read more here.
Keywords: sirt1; dox induced; induced cardiotoxicity; dox ... See more keywords
SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-19102-2
Abstract: Mitophagy, the selective degradation of mitochondria by autophagy, is crucial for the maintenance of healthy mitochondrial pool in cells. The critical event in mitophagy is the translocation of cytosolic Parkin, a ubiquitin ligase, to the… read more here.
Keywords: parkin translocation; mitochondrial translocation; translocation; sesn2 ... See more keywords
Sestrin2 aggravates oxidative stress of neurons by decreasing the expression of Nrf2.
Sign Up to like & getrecommendations! Published in 2018 at "European Review for Medical and Pharmacological Sciences"
DOI: 10.26355/eurrev_201806_15176
Abstract: Oxidative injury is an essential part of the pathological changes of cerebral ischemia-reperfusion. Sestrin2 (Sesn2), a conserved antioxidant protein, is activated under stress to protect cells against oxidative stress. This study mainly explored the function… read more here.
Keywords: cerebral ischemia; model; sesn2; ischemia reperfusion ... See more keywords
Docosahexaenoic Acid Enhances Oxaliplatin-Induced Autophagic Cell Death via the ER Stress/Sesn2 Pathway in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11070982
Abstract: Oxaliplatin is an anticancer drug administered to colorectal cancer (CRC) patients in combination with 5-fluorouracil and antibodies (bevacizumab and cetuximab), thereby significantly improving the survival rate of CRC. However, due to various side effects associated… read more here.
Keywords: oxaliplatin induced; colorectal cancer; stress; dha ... See more keywords
Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.70211
Abstract: Mitochondrial unfold protein response (UPRmt) can induce mitophagy to protect cell from unfold protein. However, how UPRmt induces mitophagy to protect cell is not yet clear. Herein, Sesn2 was considered to be a key molecule… read more here.
Keywords: degeneration; protein response; sesn2; intervertebral disc ... See more keywords