New Sesquiterpene Lactone from Inula britannica
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DOI: 10.1007/s10600-020-03168-y
Abstract: A new sesquiterpene lactone that was called inulonolide was isolated from Inula britannica. Its structure was established as 2-keto-1β,10β-epoxy-5,7,8,11α(H)-guai-3-en-8,12-olide based on spectral data and an X-ray crystal structure analysis. read more here.
Keywords: new sesquiterpene; inula britannica; sesquiterpene lactone;
Pulchelloid A, a sesquiterpene lactone from the Canadian prairie plant Gaillardia aristata inhibits mitosis in human cells.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06554-z
Abstract: BACKGROUND The Canadian prairie ecosystem presents a rich source of natural products from plants that are subjected to herbivory by grazing mammals. This type of ecological competition may contribute to the production of natural products… read more here.
Keywords: sesquiterpene lactone; biology; prairie plant; plant gaillardia ... See more keywords
Antitumoral activity of sesquiterpene lactone diacethylpiptocarphol in mice.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.01.022
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Sesquiterpene lactones are organic compounds derived from plants that exhibit anti-inflammatory and antitumor activities being one of the locking mechanisms of action of NF-kB pathway and synthesis of cytokines such as IL-1 and… read more here.
Keywords: lactone diacethylpiptocarphol; activity sesquiterpene; activity; sesquiterpene lactone ... See more keywords
Cognitive enhancement and neuroprotective effects of OABL, a sesquiterpene lactone in 5xFAD Alzheimer's disease mice model
Sign Up to like & getrecommendations! Published in 2022 at "Redox Biology"
DOI: 10.1016/j.redox.2022.102229
Abstract: Alzheimer's disease (AD) is a neurodegenerative disease in which oxidative stress and neuroinflammation were demonstrated to be associated with neuronal loss and cognitive deficits. However, there are still no specific treatments that can prevent the… read more here.
Keywords: neuroprotective effects; mice; oabl; alzheimer disease ... See more keywords
Discovery of Novel Sesquiterpene Lactone Derivatives as Potent PKM2 Activators for the Treatment of Ulcerative Colitis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01856
Abstract: The pyruvate kinase M2 (PKM2) can significantly affect the differentiation of Th17 and Treg cells; thus, it is considered a promising target for UC therapy. Herein, five series of costunolide (Cos) derivatives are designed, synthesized,… read more here.
Keywords: discovery novel; th17 treg; sesquiterpene lactone; colitis ... See more keywords
Purpurolide A, 5/5/5 Spirocyclic Sesquiterpene Lactone in Nature from the Endophytic Fungus Penicillium purpurogenum.
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DOI: 10.1021/acs.orglett.8b03323
Abstract: Purpurolide A (1), an unprecedent sesquiterpene lactone with a rarely encountered 5/5/5 spirocyclic skeleton, along with two new 6/4/5/5 tetracyclic sesquiterpene lactones (2 and 3), were isolated from the cultures of the endophytic fungus Penicillium… read more here.
Keywords: endophytic fungus; sesquiterpene; fungus penicillium; penicillium purpurogenum ... See more keywords
Production of Plant Sesquiterpene Lactone Parthenolide in the Yeast Cell Factory.
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DOI: 10.1021/acssynbio.2c00132
Abstract: Parthenolide, a kind of sesquiterpene lactone, is the direct precursor for the promising anti-glioblastoma drug ACT001. Compared with traditional parthenolide source from plant extraction, de novo biosynthesis of parthenolide in microorganisms has the potential to… read more here.
Keywords: production plant; parthenolide; sesquiterpene lactone; plant ... See more keywords
Britannin a Sesquiterpene Lactone from Inula aucheriana Exerted an Anti-leukemic Effect in Acute Lymphoblastic Leukemia (ALL) Cells and Enhanced the Sensitivity of the Cells to Vincristine.
Sign Up to like & getrecommendations! Published in 2021 at "Nutrition and cancer"
DOI: 10.1080/01635581.2021.1931700
Abstract: Since chemotherapy drugs have dose-related side effects, there is still a need for finding new agents with suitable cytotoxic effects without any harmful effects. For this purpose, we evaluated the cytotoxic effects of Britannin that… read more here.
Keywords: cytotoxic effects; inula aucheriana; lactone; acute lymphoblastic ... See more keywords
Cytotoxicity and molecular docking analysis of racemolactone I, a new sesquiterpene lactone isolated from Inula racemosa
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DOI: 10.1080/13880209.2021.1946090
Abstract: Abstract Context Traditionally, Inula racemosa Hook. f. (Asteraceae) has been reported to be effective in cancer treatment which motivated the authors to explore the plant for novel anticancer compounds. Objective To isolate and characterize new… read more here.
Keywords: molecular docking; sesquiterpene lactone; inula racemosa;
Two new sesquiterpene lactone glycosides from Cnicus benedictus
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DOI: 10.1080/14786419.2017.1295239
Abstract: Abstract Two new sesquiterpene lactone glycosides, namely melitensin 15-O-β-D-glucoside (1) and 11β,13-dihydrosalonitenolide 15-O-β-D-glucoside (2), along with eight known compounds (3–10) were isolated from the aerial part of Cnicus benedictus L. Their structures were elucidated from… read more here.
Keywords: lactone; two new; lactone glycosides; new sesquiterpene ... See more keywords
Isolation and In Silico Anti-COVID-19 Main Protease (Mpro) Activities of Flavonoids and a Sesquiterpene Lactone from Artemisia sublessingiana
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DOI: 10.1155/2021/5547013
Abstract: The emergence of the COVID-19 pandemic declared the huge need of humanity for new and effective antiviral drugs The reported antimicrobial activities of Artemisia sublessingiana encouraged us to investigate the ethanol extract of its aerial… read more here.
Keywords: covid main; artemisia sublessingiana; chemistry; covid ... See more keywords