Sestrin 3 Protects Against Diet‐Induced Nonalcoholic Steatohepatitis in Mice Through Suppression of Transforming Growth Factor β Signal Transduction
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30820
Abstract: Sestrin 3 (Sesn3) belongs to the three‐member sestrin protein family. Sestrins have been implicated in antioxidative stress, adenosine monophosphate–activated protein kinase and mammalian target of rapamycin signal transduction, and metabolic homeostasis. However, the role of… read more here.
Keywords: nonalcoholic steatohepatitis; sesn3; diet induced; mice ... See more keywords
Sestrin 2 attenuates neonatal rat cardiomyocyte hypertrophy induced by phenylephrine via inhibiting ERK1/2
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3020-2
Abstract: Cardiac hypertrophy is an adaptive response triggered by many physiological and pathological conditions and will lead to heart failure eventually. Sestrin 2, which is a stress-responsive protein, was reported to protect heart from ischemia reperfusion… read more here.
Keywords: hypertrophy induced; cardiomyocyte hypertrophy; induced phenylephrine; hypertrophy ... See more keywords
A paradoxical role for sestrin 2 protein in tumor suppression and tumorigenesis
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Cell International"
DOI: 10.1186/s12935-021-02317-9
Abstract: Sestrin 2, a highly conserved stress-induced protein, participates in the pathological processes of metabolic and age-related diseases. This p53-inducible protein also regulates cell growth and metabolism, which is closely related to malignant tumorigenesis. Sestrin 2… read more here.
Keywords: suppression tumorigenesis; tumorigenesis; paradoxical role; cancer ... See more keywords