NSD3, a member of nuclear receptor‐binding SET domain family, is a potential prognostic biomarker for pancreatic cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5774
Abstract: Members of the nuclear receptor‐binding SET domain (NSD) family of histone H3 lysine 36 methyltransferases comprise NSD1, NSD2 (MMSET/WHSC1), and NSD3 (Wolf–Hirschhorn syndrome candidate 1‐like 1, WHSC1L1). While the expression of NSD genes is essential… read more here.
Keywords: receptor binding; set domain; nuclear receptor; cancer ... See more keywords
Adversarial open set domain adaptation via progressive selection of transferable target samples
Sign Up to like & getrecommendations! Published in 2020 at "Neurocomputing"
DOI: 10.1016/j.neucom.2020.05.032
Abstract: Abstract In recent years, many Unsupervised Domain Adaptation (UDA) methods have been proposed to tackle the domain shift problem. Most existing UDA methods are derived for Close Set Domain Adaptation (CSDA) in which source and… read more here.
Keywords: set domain; target samples; target; domain adaptation ... See more keywords
Dissecting the Kinetic Mechanism of Human Lysine Methyltransferase 2D and Its Interactions with the WRAD2 Complex
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00385
Abstract: Human lysine methyltransferase 2D (hKMT2D) is an epigenetic writer catalyzing the methylation of histone 3 lysine 4. hKMT2D by itself has little catalytic activity and reaches full activation as part of the WRAD2 complex, additionally… read more here.
Keywords: set domain; wrad2 complex; human lysine; mechanism ... See more keywords
Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00807
Abstract: Overexpression of nuclear receptor binding SET domain protein 2 (NSD2) is frequent in multiple myeloma (MM). However, existing NSD2 inhibitors are largely ineffective in suppressing MM cell proliferation. Here, we report the discovery of a… read more here.
Keywords: receptor binding; set domain; nuclear receptor; domain protein ... See more keywords
Complete loss of H3K9 methylation dissolves mouse heterochromatin organization
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24532-8
Abstract: Histone H3 lysine 9 (H3K9) methylation is a central epigenetic modification that defines heterochromatin from unicellular to multicellular organisms. In mammalian cells, H3K9 methylation can be catalyzed by at least six distinct SET domain enzymes:… read more here.
Keywords: heterochromatin organization; methylation; h3k9 methylation; set domain ... See more keywords
Identification and characterization of SET domain family genes in bread wheat (Triticum aestivum L.)
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-71526-5
Abstract: SET domain genes (SDGs) that are involved in histone methylation have been examined in many plant species, but have never been examined in bread wheat; the histone methylation caused due to SDGs is associated with… read more here.
Keywords: set domain; expression; tasdgs; identification characterization ... See more keywords
Altered Levels of Negative Costimulatory Molecule V-Set Domain-Containing T-Cell Activation Inhibitor-1 (VTCN1) and Metalloprotease Nardilysin (NRD1) are Associated with Generalized Active Vitiligo
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Investigations"
DOI: 10.1080/08820139.2022.2097091
Abstract: ABSTRACT Background Vitiligo is characterized by depigmented macules on the skin caused due to autoimmune destruction of melanocytes. V-set domain-containing T-cell activation inhibitor-1 (VTCN1) is a negative costimulatory molecule that plays a vital role in… read more here.
Keywords: set domain; vtcn1; containing cell; cell activation ... See more keywords
The role of SET domain containing lysine methyltransferase 7 in tumorigenesis and development
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2022.2122257
Abstract: ABSTRACT SET domain containing lysine methyltransferase 7 (SETD7) belongs to the protein lysine methyltransferase family and can catalyze the monomethylation of histone H3K4, which plays a vital role in the regulation of cell cycle, cell… read more here.
Keywords: set domain; role; tumor; development ... See more keywords
Adversarial Network With Multiple Classifiers for Open Set Domain Adaptation
Sign Up to like & getrecommendations! Published in 2021 at "IEEE Transactions on Multimedia"
DOI: 10.1109/tmm.2020.3016126
Abstract: Domain adaptation aims to transfer knowledge from a domain with adequate labeled samples to a domain with scarce labeled samples. Prior research has introduced various open set domain adaptation settings in the literature to extend… read more here.
Keywords: set domain; target; domain adaptation; domain ... See more keywords
Open Set Domain Adaptation: Theoretical Bound and Algorithm
Sign Up to like & getrecommendations! Published in 2021 at "IEEE Transactions on Neural Networks and Learning Systems"
DOI: 10.1109/tnnls.2020.3017213
Abstract: The aim of unsupervised domain adaptation is to leverage the knowledge in a labeled (source) domain to improve a model’s learning performance with an unlabeled (target) domain—the basic strategy being to mitigate the effects of… read more here.
Keywords: domain adaptation; set domain; open set; target ... See more keywords
Uncertainty-Aware Aggregation for Federated Open Set Domain Adaptation.
Sign Up to like & getrecommendations! Published in 2022 at "IEEE transactions on neural networks and learning systems"
DOI: 10.1109/tnnls.2022.3214930
Abstract: Open set domain adaptation (OSDA) methods have been proposed to leverage the difference between the source and target domains, as well as to recognize the known and unknown classes in the target domain. Such methods… read more here.
Keywords: domain adaptation; set domain; uncertainty aware; uncertainty ... See more keywords