Gene set enrichment analysis and expression pattern exploration implicate an involvement of neurodevelopmental processes in bipolar disorder.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2017.11.068
Abstract: BACKGROUND Bipolar disorder (BD) is a common and highly heritable disorder of mood. Genome-wide association studies (GWAS) have identified several independent susceptibility loci. In order to extract more biological information from GWAS data, multi-locus approaches… read more here.
Keywords: gene set; set enrichment; expression; bipolar disorder ... See more keywords
iMSEA: A Novel Metabolite Set Enrichment Analysis Strategy to Decipher Drug Interactions.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04603
Abstract: Drug combinations are commonly used to treat various diseases to achieve synergistic therapeutic effects or to alleviate drug resistance. Nevertheless, some drug combinations might lead to adverse effects, and thus, it is crucial to explore… read more here.
Keywords: imsea; set enrichment; drug interactions; metabolite set ... See more keywords
Differential Gene Set Enrichment Analysis: A statistical approach to quantify the relative enrichment of two gene sets.
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa658
Abstract: MOTIVATION Gene Set Enrichment Analysis (GSEA) is an algorithm widely used to identify statistically enriched gene sets in transcriptomic data. However, GSEA cannot examine the enrichment of two gene sets or pathways relative to one… read more here.
Keywords: gene set; enrichment analysis; dgsea; set enrichment ... See more keywords
blitzGSEA: efficient computation of gene set enrichment analysis through gamma distribution approximation
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac076
Abstract: MOTIVATION The identification of pathways and biological processes from differential gene expression is central for interpretation of data collected by transcriptomics assays. Gene-Set Enrichment Analysis (GSEA) is the most common used algorithm to calculate the… read more here.
Keywords: set enrichment; enrichment analysis; gene set; gene ... See more keywords
BAGSE: a Bayesian hierarchical model approach for gene set enrichment analysis
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz831
Abstract: MOTIVATION Gene set enrichment analysis has been shown to be effective in identifying relevant biological pathways underlying complex diseases. Existing approaches lack the ability to quantify the enrichment levels accurately, hence preventing the enrichment information… read more here.
Keywords: gene set; enrichment analysis; set enrichment; hierarchical model ... See more keywords
FUNAGE-Pro: comprehensive web server for gene set enrichment analysis of prokaryotes
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac441
Abstract: Abstract Recent advances in the field of high throughput (meta-)transcriptomics and proteomics call for easy and rapid methods enabling to explore not only single genes or proteins but also extended biological systems. Gene set enrichment… read more here.
Keywords: funage pro; set enrichment; enrichment analysis; analysis ... See more keywords
PANGEA: a new gene set enrichment tool for Drosophila and common research organisms.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad331
Abstract: Gene set enrichment analysis (GSEA) plays an important role in large-scale data analysis, helping scientists discover the underlying biological patterns over-represented in a gene list resulting from, for example, an 'omics' study. Gene Ontology (GO)… read more here.
Keywords: tool; set enrichment; drosophila; analysis ... See more keywords
Avoiding the pitfalls of gene set enrichment analysis with SetRank
Sign Up to like & getrecommendations! Published in 2017 at "BMC Bioinformatics"
DOI: 10.1186/s12859-017-1571-6
Abstract: BackgroundThe purpose of gene set enrichment analysis (GSEA) is to find general trends in the huge lists of genes or proteins generated by many functional genomics techniques and bioinformatics analyses.ResultsHere we present SetRank, an advanced… read more here.
Keywords: gene set; enrichment analysis; set enrichment; gene ... See more keywords
Ranking metrics in gene set enrichment analysis: do they matter?
Sign Up to like & getrecommendations! Published in 2017 at "BMC Bioinformatics"
DOI: 10.1186/s12859-017-1674-0
Abstract: BackgroundThere exist many methods for describing the complex relation between changes of gene expression in molecular pathways or gene ontologies under different experimental conditions. Among them, Gene Set Enrichment Analysis seems to be one of… read more here.
Keywords: gene set; enrichment analysis; analysis; set enrichment ... See more keywords
TLSEA: a tool for lncRNA set enrichment analysis based on multi-source heterogeneous information fusion
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1181391
Abstract: Long non-coding RNAs (lncRNAs) play an important regulatory role in gene transcription and post-transcriptional modification, and lncRNA regulatory dysfunction leads to a variety of complex human diseases. Hence, it might be beneficial to detect the… read more here.
Keywords: information; set enrichment; enrichment analysis; analysis ... See more keywords
Gene Set Enrichment Analysis and Genetic Experiment Reveal Changes in Cell Signaling Pathways Induced by α-Synuclein Overexpression
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11020263
Abstract: Abnormal accumulation of alpha synuclein (α-Syn) in sporadic and familial Parkinson’s disease (PD) may be a key step in its pathogenesis. In this study, the expression matrix of the GSE95427 dataset after α-Syn overexpression in… read more here.
Keywords: set enrichment; enrichment analysis; overexpression; analysis ... See more keywords