Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical science"
DOI: 10.1042/cs20220466
Abstract: Cardiovascular diseases are the main cause of death worldwide. Recent studies have revealed the influence of histone-modifying enzymes in cardiac remodeling and heart dysfunction. The Set7 methyltransferase regulates the expression of several genes through the… read more here.
Keywords: isoproterenol induced; set7; set7 deletion; dysfunction ... See more keywords
The Role of Lysine Methyltransferase SET7/9 in Proliferation and Cell Stress Response
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DOI: 10.3390/life12030362
Abstract: Lysine-specific methyltransferase 7 (KMT7) SET7/9, aka Set7, Set9, or SetD7, or KMT5 was discovered 20 years ago, yet its biological role remains rather enigmatic. In this review, we analyze the particularities of SET7/9 enzymatic activity… read more here.
Keywords: set7; stress response; methyltransferase; proliferation ... See more keywords
SET7/9 promotes hepatocellular carcinoma progression through regulation of E2F1
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DOI: 10.3892/or.2018.6621
Abstract: Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide. Histone-lysine N-methyltransferase SET7/9 is a protein lysine monomethylase that methylates histone H3K4 as well as various non-histone proteins. Deregulation of SET7/9 is frequently detected… read more here.
Keywords: hepatocellular carcinoma; hcc; hcc cells; set7 ... See more keywords
Oncogene or Tumor Suppressor: The Coordinative Role of Lysine Methyltransferase SET7/9 in Cancer Development and the Related Mechanisms
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DOI: 10.7150/jca.57663
Abstract: SET7/9 is a member of the protein lysine methyltransferase family that methylates both histone 3 lysine 4 (H3-K4) and lysine(s) of other non-histone proteins. In recent years, dis-regulation of SET7/9 were frequently detected in various… read more here.
Keywords: set7; cancer; oncogene tumor; development ... See more keywords