SET8 localization to chromatin flanking DNA damage is dependent on RNF168 ubiquitin ligase
Sign Up to like & getrecommendations! Published in 2019 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1690231
Abstract: ABSTRACT The DNA damage response (DDR) associated post-translational modifications recruit chromatin remodelers, signaling proteins such as 53BP1 and repair factors to chromatin flanking DNA double strand breaks (DSBs) to promote its repair. Although localization of… read more here.
Keywords: dna damage; chromatin flanking; rnf168; damage ... See more keywords
Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in Drosophila melanogaster.
Sign Up to like & getrecommendations! Published in 2022 at "Genetics"
DOI: 10.1093/genetics/iyac054
Abstract: Mono-methylation of histone H4 lysine 20 (H4K20me1) is catalyzed by Set8/KMT5A and regulates numerous aspects of genome organization and function. Loss-of-function mutations in Drosophila melanogaster Set8 or mammalian KMT5A prevent H4K20me1 and disrupt development. Set8/KMT5A… read more here.
Keywords: histone; kmt5a; development; set8 ... See more keywords
SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1
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DOI: 10.1093/nar/gkz626
Abstract: Abstract Faithful inheritance of DNA methylation across cell division requires DNMT1 and its accessory factor UHRF1. However, how this axis is regulated to ensure DNA methylation homeostasis remains poorly understood. Here we show that SET8,… read more here.
Keywords: methylation; dna methylation; uhrf1 dnmt1; set8 ... See more keywords
Mechanism of SET8 Activates the Nrf2-KEAP1-ARE Signaling Pathway to Promote the Recovery of Motor Function after Spinal Cord Injury
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DOI: 10.1155/2023/4420592
Abstract: Background Spinal cord injury (SCI) is a common injury of the central nervous system (CNS), and astrocytes are relatively abundant glial cells in the CNS that impairs the recovery of motor function after SCI. It… read more here.
Keywords: sci; function; motor function; set8 ... See more keywords
Abstract 3834: Histone methyltransferase SET8 is regulated by miR-192/-215 and induces oncogene-induced senescence via p53-dependent DNA damage in human gastric carcinoma cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-3834
Abstract: Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA Purpose: This aim of study was to investigate the clinicopathologic significance and potential role of histone methyltransferase SET8 in the progression… read more here.
Keywords: 192 215; histone methyltransferase; senescence; mir 192 ... See more keywords
Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferase
Sign Up to like & getrecommendations! Published in 2021 at "Life Science Alliance"
DOI: 10.26508/lsa.202000919
Abstract: Cryo-EM structures of the human SET8–nucleosome complexes reveal the mechanism by which the SET8 methyltransferase binds the nucleosome and specifically recognizes the histone H4 lysine-20 residue. SET8 is solely responsible for histone H4 lysine-20 (H4K20)… read more here.
Keywords: set8; h4k20 monomethylation; histone lysine; set8 methyltransferase ... See more keywords
LukS-PV Induces Apoptosis via the SET8-H4K20me1-PIK3CB Axis in Human Acute Myeloid Leukemia Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.718791
Abstract: Evidence suggests that histone modification disorders are involved in leukemia pathogenesis. We previously reported that LukS-PV, a component of Panton–Valentine leukocidin (PVL), has antileukemia activities that can induce differentiation, increase apoptosis, and inhibit proliferation of… read more here.
Keywords: apoptosis; myeloid leukemia; pik3cb; h4k20me1 ... See more keywords