Tumor Cell‐Intrinsic SETD2 Deficiency Reprograms Neutrophils to Foster Immune Escape in Pancreatic Tumorigenesis
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DOI: 10.1002/advs.202202937
Abstract: Genetic and epigenetic alterations play central roles in shaping the immunosuppressive tumor microenvironment (TME) to evade immune surveillance. The previous study shows that SETD2‐H3K36me3 loss promotes KRAS‐induced pancreatic tumorigenesis. However, little is known about its… read more here.
Keywords: setd2 deficiency; immune escape; escape pancreatic; pancreatic tumorigenesis ... See more keywords
SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS
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DOI: 10.1182/blood.2019001963
Abstract: SETD2, the histone H3 lysine 36 methyltransferase, previously identified by us, plays an important role in the pathogenesis of hematologic malignancies, but its role in myelodysplastic syndromes (MDSs) has been unclear. In this study, low… read more here.
Keywords: setd2 deficiency; s100a9; mds associated; mds ... See more keywords