SETD2 haploinsufficiency enhances germinal center-associated AICDA somatic hypermutation to drive B cell lymphomagenesis.
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DOI: 10.1158/2159-8290.cd-21-1514
Abstract: SETD2 is the sole histone methyltransferase responsible for H3K36me3, with roles in splicing, transcription initiation and DNA damage response. Homozygous disruption of SETD2 yields a tumor suppressor effect in various cancers. However, SETD2 mutation is… read more here.
Keywords: lymphomagenesis; dna damage; somatic hypermutation; setd2 haploinsufficiency ... See more keywords