SETD2 and histone H3 lysine 36 methylation deficiency in advanced systemic mastocytosis
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DOI: 10.1038/leu.2017.183
Abstract: The molecular basis of advanced systemic mastocytosis (SM) is not fully understood and despite novel therapies the prognosis remains dismal. Exome sequencing of an index-patient with mast cell leukemia (MCL) uncovered biallelic loss-of-function mutations in… read more here.
Keywords: setd2 histone; setd2; systemic mastocytosis; advanced systemic ... See more keywords