SETD2 regulates chromatin accessibility and transcription to suppress lung tumorigenesis
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DOI: 10.1172/jci.insight.154120
Abstract: SETD2, a H3K36 trimethyltransferase, is the most frequently mutated epigenetic modifier in lung adenocarcinoma, with a mutation frequency of approximately 9%. However, how SETD2 loss of function promotes tumorigenesis remains unclear. Using conditional Setd2-KO mice,… read more here.
Keywords: tumorigenesis; setd2 loss; lung; setd2 ... See more keywords