Stabilization of SETD3 by deubiquitinase USP27 enhances cell proliferation and hepatocellular carcinoma progression
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-04118-9
Abstract: The histone methyltransferase SETD3 plays critical roles in various biological events, and its dysregulation is often associated with human diseases including cancer. However, the underlying regulatory mechanism remains elusive. Here, we reported that ubiquitin-specific peptidase… read more here.
Keywords: cell proliferation; hepatocellular carcinoma; stabilization setd3; setd3 ... See more keywords
Structure and Dynamics of the Reactive State for the Histidine Methylation Process and Catalytic Mechanism of SETD3: Insights from Quantum Mechanics/Molecular Mechanics Investigation
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DOI: 10.1021/acscatal.0c03390
Abstract: The SETD3 enzyme adds a methyl group to Ne2 of His73 in β-actin, and such methylation finetunes actin’s biochemical properties and cellular function. Here, quantum mechanics/molecular mechanics mol... read more here.
Keywords: methylation; molecular mechanics; mechanics molecular; setd3 ... See more keywords
Phenotypic characterization of SETD3 knockout Drosophila
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DOI: 10.1371/journal.pone.0201609
Abstract: Lysine methylation is a reversible post-translational modification that affects protein function. Lysine methylation is involved in regulating the function of both histone and non-histone proteins, thereby influencing both cellular transcription and the activation of signaling… read more here.
Keywords: drosophila; phenotypic characterization; setd3; dsetd3 ... See more keywords
SETD3 Methyltransferase Regulates PLK1 Expression to Promote In Situ Hepatic Carcinogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.882202
Abstract: Background The development of a new strategy to overcome chemoresistance to hepatocellular carcinoma (HCC) treatment is a long-standing issue. We have previously found that upregulated SETD3 levels are closely correlated with HCC. This study aims… read more here.
Keywords: cell; expression; setd3; hepatic carcinogenesis ... See more keywords