SET domain containing 7 promotes oxygen-glucose deprivation/reoxygenation-induced PC12 cell inflammation and oxidative stress by regulating Keap1/Nrf2/ARE and NF-κB pathways
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DOI: 10.1080/21655979.2022.2045830
Abstract: ABSTRACT Oxidative stress and inflammation are implicated in the pathogenesis of cerebral ischemia-reperfusion (I/R) injury. SETD7 (SET Domain Containing 7) functions as a histone lysine methyltransferase, participates in cardiac lineage commitment, and silence of SETD7… read more here.
Keywords: cell; inflammation; pc12; oxidative stress ... See more keywords
Methylation of the Hippo effector YAP by the methyltransferase SETD7 drives myocardial ischemic injury: a translational study.
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DOI: 10.1093/cvr/cvac102
Abstract: AIMS Methylation of non-histone proteins is emerging as a central regulatory mechanism in health and disease. The methyltransferase SETD7 has shown to methylate and alter the function of a variety of proteins in vitro, however… read more here.
Keywords: methylation; myocardial ischemic; ischemic injury; setd7 ... See more keywords
Methylation of the hippo signalling effector YAP by SETD7 drives myocardial ischemic injury
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DOI: 10.1093/ehjci/ehaa946.3636
Abstract: Myocardial ischemia/reperfusion (I/R) injury is one of the most deleterious cardiovascular conditions and a leading cause of mortality. The Hippo pathway effector YAP critically regulates cardiomyocyte proliferation and survival during myocardial I/R injury. However, the… read more here.
Keywords: hippo; methylation; effector yap; setd7 ... See more keywords
P5378The methyltransferase SETD7 promotes myocardial ischemic injury by activating Hippo signalling
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DOI: 10.1093/eurheartj/ehz746.0339
Abstract: Despite significant advances in coronary revascularization, acute myocardial infarction remains the leading cause of heart failure and death worldwide. The Hippo pathway is a master regulator of cell survival during myocardial ischemia. Upon cellular stress,… read more here.
Keywords: hippo; microscopy; methyltransferase setd7; setd7 ... See more keywords
LncRNA SNHG15 regulates hypoxic-ischemic brain injury via miR-153-3p/SETD7 axis.
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DOI: 10.14670/hh-18-489
Abstract: Hypoxic-ischemic encephalopathy (HIE) is a leading cause of fatality and morbidity in newborns. Long non-coding RNAs (lncRNAs) Small Nucleolar RNA Host Gene 15 (SNHG15) was elevated in the peripheral blood of patients with acute cerebral… read more here.
Keywords: snhg15; mir 153; brain; setd7 ... See more keywords
A Systematic Review to Define the Multi-Faceted Role of Lysine Methyltransferase SETD7 in Cancer
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DOI: 10.3390/cancers14061414
Abstract: Simple Summary The protein methyltransferase SETD7 is essential for epigenetic regulation through methylation of histone H3 and non-histone proteins, including cell cycle, apoptosis and metastasis regulators. This multi-faceted role of SETD7 is cell context-and tissue… read more here.
Keywords: systematic review; setd7; cancer; methyltransferase setd7 ... See more keywords
SETD7 Expression Is Associated with Breast Cancer Survival Outcomes for Specific Molecular Subtypes: A Systematic Analysis of Publicly Available Datasets
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DOI: 10.3390/cancers14246029
Abstract: Simple Summary Breast cancer is the most common cancer among women, and it can be classified into subtypes with distinct biology and prognosis. The aim of our bioinformatic study was to assess the potential role… read more here.
Keywords: breast cancer; setd7; cancer; setd7 expression ... See more keywords