IL‐7 germline variant: setting the stage for immune‐related adverse events
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13392
Abstract: Treatment with immune checkpoint inhibitors (ICIs) is frequently associated with immune‐related adverse events (irAEs). A new study identified an interleukin 7 (IL‐7) allelic variant—rs16906115—as a major risk factor for the development of ICI‐associated irAEs. This… read more here.
Keywords: variant setting; germline variant; immune related; related adverse ... See more keywords
Setting the stage for a role of the postsynaptic proteome in inherited neurometabolic disorders
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Inherited Metabolic Disease"
DOI: 10.1007/s10545-018-0240-x
Abstract: Neurotransmitter diseases are a well-defined group of metabolic conditions caused, in most instances, by genes specifically expressed in the presynaptic button. Better understanding of presynaptic molecular physiology, both in normal and pathological conditions, should help… read more here.
Keywords: role postsynaptic; stage role; setting stage; role ... See more keywords
Dynamic Looping Interactions: Setting the 3D Stage for the Macrophage.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.09.011
Abstract: The mechanisms by which 3D chromatin looping interactions mediate cell type-specific gene expression are an active area of investigation. In this issue of Molecular Cell, Phanstiel et al. (2017) annotate five classes of loops during macrophage development… read more here.
Keywords: interactions setting; dynamic looping; looping interactions; stage macrophage ... See more keywords
Double‐negative T cells: Setting the stage for disease control or progression
Sign Up to like & getrecommendations! Published in 2021 at "Immunology"
DOI: 10.1111/imm.13441
Abstract: Double‐negative (DN) T cells are present at relatively low frequencies in human peripheral blood, and are characterized as expressing the alpha‐beta or gamma‐delta T‐cell receptor (TCR), but not the CD4 nor the CD8 co‐receptors. Despite… read more here.
Keywords: negative cells; double negative; setting stage; cells setting ... See more keywords
Setting the Stage to Flourish: Supporting LGBTQIA2S+ Graduate Students.
Sign Up to like & getrecommendations! Published in 2023 at "Health promotion practice"
DOI: 10.1177/15248399231157329
Abstract: The lived experiences of LGBTQIA2S+ (Lesbian, Gay, Bisexual, Transgender, Queer/Questioning, Intersex, Asexual, Two Spirit) doctoral students remain an area for deeper exploration and understanding in the higher education landscape. Higher education administrators and faculty often… read more here.
Keywords: supporting lgbtqia2s; stage flourish; lived experiences; student ... See more keywords
Setting a stage: Inflammation during preeclampsia and postpartum
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1130116
Abstract: Preeclampsia (PE) is a leading cause of maternal and fetal mortality worldwide. The immune system plays a critical role in normal pregnancy progression; however, inappropriate inflammatory responses have been consistently linked with PE pathophysiology. This… read more here.
Keywords: inflammation; stage inflammation; inflammation preeclampsia; preeclampsia ... See more keywords