Changes in oxidative RNA and DNA modifications following one-week treatment with sevelamer: two randomized, placebo-controlled trials
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.288
Abstract: Introduction Sevelamer is a phosphate-binding drug used in the treatment of chronic kidney disease. Studies have shown that sevelamer reduces oxidative stress measured as 8-isoprostanes. Oxidative RNA modifications are associated with increased cardiovascular as well… read more here.
Keywords: sevelamer; treatment sevelamer; treatment; oxidative rna ... See more keywords
The efficacy and safety of sevelamer and lanthanum versus calcium-containing and iron-based binders in treating hyperphosphatemia in patients with chronic kidney disease: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2017 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfw312
Abstract: Background. It remains unclear which phosphate binders should be preferred for hyperphosphatemia management in chronic kidney disease (CKD). Methods. We performed a systematic review and meta-analysis of randomized trials comparing sevelamer or lanthanum with other… read more here.
Keywords: sevelamer; based binders; chronic kidney; lanthanum ... See more keywords
Glucose‐lowering effects and mechanisms of the bile acid‐sequestering resin sevelamer
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DOI: 10.1111/dom.13272
Abstract: Sevelamer, a non‐absorbable amine‐based resin used for treatment of hyperphosphataemia, has been demonstrated to have a marked bile acid‐binding potential alongside beneficial effects on lipid and glucose metabolism. The aim of this study was to… read more here.
Keywords: sevelamer; resin; effects mechanisms; bile acid ... See more keywords
Effects of different phosphate lowering strategies in patients with CKD on laboratory outcomes: A systematic review and NMA
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DOI: 10.1371/journal.pone.0171028
Abstract: Background Chronic kidney disease-mineral and bone disorder (CKD-MBD), a complication of chronic kidney disease, has been linked to reduced quality and length of life. High serum phosphate levels that result from CKD-MBD require phosphate-lowering agents,… read more here.
Keywords: sevelamer; systematic review; serum; calcium ... See more keywords
Case report: Sevelamer-associated colitis—a cause of pseudotumor formation with colon perforation and life-threatening bleeding
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.1097469
Abstract: Chronic kidney disease (CKD) is a very common chronic non-communicable disease. Phosphate and calcium metabolism disorders are one of the most common features of CKD. Sevelamer carbonate is the most widely used non-calcium phosphate binder.… read more here.
Keywords: case report; cause; colon; sevelamer ... See more keywords