Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.09.007
Abstract: G-protein-coupled receptors (GPCRs), also known as seven transmembrane receptors (7TMRs), typically interact with two distinct signal-transducers, i.e., G proteins and β-arrestins (βarrs). Interestingly, there are some non-canonical 7TMRs that lack G protein coupling but interact… read more here.
Keywords: intrinsic bias; bias non; transmembrane receptors; seven transmembrane ... See more keywords
Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.06.20.496907
Abstract: TMEM87s are eukaryotic transmembrane proteins with two members (TMEM87A and TMEM87B) in humans. TMEM87s have proposed roles in protein transport to and from the Golgi, as mechanosensitive ion channels, and in developmental signaling. TMEM87 disruption… read more here.
Keywords: tmem87a; transmembrane helix; domain; seven transmembrane ... See more keywords