One oncogene, several vulnerabilities: EWS/FLI targeted therapies for Ewing sarcoma
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DOI: 10.1016/j.jbo.2021.100404
Abstract: Highlights • EWS/FLI is the driver oncogene of Ewing sarcoma.• EWS-FLI driven transcription yields numerous therapeutic vulnerabilities.• The intrinsic cellular stress of dysregulated transcription leads to additional therapeutic vulnerabilities.• A number of compounds targeting various… read more here.
Keywords: oncogene several; several vulnerabilities; ews fli; ewing sarcoma ... See more keywords