Hyperoxidized albumin modulates neutrophils to induce oxidative stress and inflammation in severe alcoholic hepatitis
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28897
Abstract: Albumin is a potent scavenger of reactive oxygen species (ROS). However, modifications in albumin structure may reduce its antioxidant properties and modulate its immune‐regulatory functions. We examined alterations in circulating albumin in severe alcoholic hepatitis… read more here.
Keywords: severe alcoholic; stress; albumin; sah ... See more keywords
Main drivers of outcome differ between short term and long term in severe alcoholic hepatitis: A prospective study
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.29240
Abstract: Understanding the mechanisms of outcome according to the time frame can help optimize the therapeutic development in severe alcoholic hepatitis. We assessed short‐term and long‐term survival in severe alcoholic hepatitis based on baseline disease severity,… read more here.
Keywords: term; long term; severe alcoholic; day ... See more keywords
Good outcome of living donor liver transplantation for severe alcoholic hepatitis not responding to medical management: A single center experience of 39 patients.
Sign Up to like & getrecommendations! Published in 2019 at "Alcohol"
DOI: 10.1016/j.alcohol.2018.07.009
Abstract: INTRODUCTION There are limited data on outcomes of living donor liver transplantation (LDLT) for patients with severe alcoholic hepatitis. METHODS The study included LDLT recipients for severe alcoholic hepatitis (n = 39) who did not improve with… read more here.
Keywords: hepatitis; severe alcoholic; liver transplantation; donor liver ... See more keywords
Homozygosity for rs738409:G in PNPLA3 is associated with increased mortality following an episode of severe alcoholic hepatitis.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2017.01.018
Abstract: BACKGROUND & AIMS Carriage of rs738409:G in PNPLA3 is associated with an increased risk of developing alcohol-related cirrhosis and has a significant negative effect on survival. Short-term mortality in patients with severe alcoholic hepatitis is… read more here.
Keywords: rs738409 pnpla3; alcoholic hepatitis; severe alcoholic; mortality ... See more keywords
Epigenetic basis for monocyte dysfunction in patients with severe alcoholic hepatitis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2020.02.017
Abstract: BACKGROUND & AIMS Severe forms of alcohol-related liver disease are associated with increased susceptibility to infections contributing to their poor prognosis. The cellular and molecular mechanisms responsible for this altered host defense are incompletely understood.… read more here.
Keywords: basis monocyte; severe alcoholic; epigenetic basis; patients sah ... See more keywords
Severe alcoholic hepatitis as precipitant for organ failure and ACLF.
Sign Up to like & getrecommendations! Published in 2022 at "Zeitschrift fur Gastroenterologie"
DOI: 10.1055/a-1713-3796
Abstract: Alcoholic hepatitis is the acute deterioration of alcoholic liver disease with rapid onset or worsening of jaundice, which in severe cases, may transition to acute-on-chronic liver failure with extremely high short-term mortality, increasing with the… read more here.
Keywords: hepatitis precipitant; failure; precipitant organ; severe alcoholic ... See more keywords
Pneumocystis pneumonia after use of corticosteroids in a man with severe alcoholic hepatitis
Sign Up to like & getrecommendations! Published in 2020 at "Medicine"
DOI: 10.1097/md.0000000000018696
Abstract: Abstract Rationale: Severe alcoholic hepatitis (AH) has a very high mortality rate. Current guidelines recommend oral corticosteroids as first-line agents in individuals with severe AH to reduce short-term mortality. However, systemic corticosteroids have serious adverse… read more here.
Keywords: individuals severe; severe alcoholic; alcoholic hepatitis; pneumocystis ... See more keywords
Three-year Results of a Pilot Program in Early Liver Transplantation for Severe Alcoholic Hepatitis
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Surgery"
DOI: 10.1097/sla.0000000000001831
Abstract: Objective: To examine our pilot to transplant selected patients with acute alcoholic hepatitis, initiated in October 2012. Background: Six months of alcohol abstinence is typically required before liver transplant. A Franco-Belgian protocol showed that early… read more here.
Keywords: group; severe alcoholic; liver; relapse ... See more keywords
Serum keratin 19 (CYFRA21‐1) is a prognostic biomarker in severe alcoholic hepatitis
Sign Up to like & getrecommendations! Published in 2022 at "Liver International"
DOI: 10.1111/liv.15218
Abstract: Up to 30% of patients with severe alcoholic hepatitis (sAH) die within 3 months of presentation. The degree of ductular reaction, characterized by accumulation of biliary and liver progenitor cells, confers a poor prognosis. Keratin… read more here.
Keywords: severe alcoholic; serum keratin; alcoholic hepatitis;
PWE-081 Low serum transferrin indicates short-term mortality in severe alcoholic hepatitis
Sign Up to like & getrecommendations! Published in 2017 at "Gut"
DOI: 10.1136/gutjnl-2017-314472.327
Abstract: Introduction Iron is simultaneously an essential and potentially toxic micronutrient linked to oxidative stress, bacterial infection and systemic inflammation. The liver plays a key role in iron homeostasis through synthesis of the serum transporter, transferrin,… read more here.
Keywords: transferrin; alcoholic hepatitis; serum transferrin; severe alcoholic ... See more keywords
P26 Methylprednisolone in treatment of severe alcoholic hepatitis not responding to prednisolone
Sign Up to like & getrecommendations! Published in 2020 at "Gut"
DOI: 10.1136/gutjnl-2020-basl.37
Abstract: Introduction Prednisolone treatment of severe alcoholic hepatitis reduces mortality from 18% to 14% at d28 (STOPAH) but not at d90 (30%). Non-response may be due to steroid-resistance which might be overcome by using intravenous methylprednisolone… read more here.
Keywords: severe alcoholic; prednisolone; treatment severe; alcoholic hepatitis ... See more keywords