Multidisciplinary treatment in children with problematic severe asthma: A prospective evaluation
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DOI: 10.1002/ppul.23623
Abstract: Objective: For children with problematic severe asthma, achieving adequate control of asthma is difficult. The aim of this prospective observational study was to evaluate the effects of intensive multidisciplinary inpatient treatment on multiple outcome variables… read more here.
Keywords: outcome; treatment; children problematic; severe asthma ... See more keywords
High prevalence of house dust mite sensitization in children with severe asthma living at high altitude in a tropical country
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.24079
Abstract: Some studies, mainly in Europe, have shown a low level of sensitization to house dust mite (HDM) allergens at high altitude (HA). Differently, some others in tropical countries have shown a higher level. The aim… read more here.
Keywords: dust mite; house dust; severe asthma; children severe ... See more keywords
Asthma control and psychological health in pediatric severe asthma
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DOI: 10.1002/ppul.25120
Abstract: Psychological comorbidities have been associated with asthma in adults and children, but have not been studied in a population of children with severe asthma. The aim of this study was to test the hypothesis that… read more here.
Keywords: pediatric severe; asthma control; severe asthma; control psychological ... See more keywords
Severe asthma in children: Description of a large multidisciplinary clinical cohort
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DOI: 10.1002/ppul.25887
Abstract: Children with severe asthma have substantial morbidity and healthcare utilization. Pediatric severe asthma is a heterogeneous disease, and a multidisciplinary approach can improve the diagnosis and management of these children. read more here.
Keywords: description large; large multidisciplinary; multidisciplinary clinical; severe asthma ... See more keywords
DNA Sequencing Analysis of Cystic Fibrosis Transmembrane Regulator Gene Identifies Cystic Fibrosis-Associated Variants in the Severe Asthma Research Program.
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DOI: 10.1002/ppul.25939
Abstract: BACKGROUND Heterozygote carriers of potentially pathogenic variants in the cystic fibrosis transmembrane conductance regulator (CFTR) gene have increased asthma risk. However, the frequency and impact of CFTR variation among individuals with asthma is unknown. OBJECTIVE… read more here.
Keywords: fibrosis transmembrane; severe asthma; cystic fibrosis; potentially pathogenic ... See more keywords
Dupilumab in children with moderate‐to‐severe asthma: A cost utility analysis
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DOI: 10.1002/ppul.26033
Abstract: Dupilumab is an effective and safe medicine for the management of severe asthma. Due to its high cost, concerns are generated regarding its cost‐effectiveness. This study aimed to estimate the cost‐utility of dupilumab plus standard… read more here.
Keywords: cost; dupilumab; severe asthma; cost utility ... See more keywords
Severe asthma guidelines in children and adolescents: A practical document for physicians
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DOI: 10.1002/ppul.26387
Abstract: Asthma is a common disease in childhood with a minority of affected children suffering from severe asthma. Patients with severe asthma require high dose inhaled glucocorticoids plus a second controller and/or systemic corticosteroids to be… read more here.
Keywords: document physicians; practical document; management; children adolescents ... See more keywords
Management of Severe Asthma Beyond the Guidelines
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DOI: 10.1007/s11882-020-00940-6
Abstract: Purpose of Review Asthma is one of the most common chronic respiratory diseases worldwide, yet only a small percentage of patients are categorized as having severe disease. Severe asthmatics, however, are responsible for the largest… read more here.
Keywords: severe asthma; management severe; review; asthma ... See more keywords
Liberty Asthma QUEST: Phase 3 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate Dupilumab Efficacy/Safety in Patients with Uncontrolled, Moderate-to-Severe Asthma
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DOI: 10.1007/s12325-018-0702-4
Abstract: IntroductionDupilumab, a fully human anti-IL-4Rα monoclonal antibody, inhibits signaling of both interleukin (IL)-4 and IL-13, which are key drivers of type 2-mediated inflammation. Dupilumab is approved in the EU, USA, and other countries for the… read more here.
Keywords: phase; severe asthma; efficacy; asthma ... See more keywords
A Charter to Improve Patient Care in Severe Asthma
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DOI: 10.1007/s12325-018-0777-y
Abstract: Severe asthma is a subtype of asthma that is difficult to treat and control. By conservative estimates, severe asthma affects approximately 5–10% of patients with asthma worldwide. Severe asthma impairs patients’ health-related quality of life,… read more here.
Keywords: care; health; severe asthma; patient care ... See more keywords
Dupilumab: A Review in Moderate to Severe Asthma
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DOI: 10.1007/s40265-019-01221-x
Abstract: Dupilumab (Dupixent®) is a fully human monoclonal antibody against the interleukin (IL)-4 receptor α subunit of IL-4 and IL-4/IL-13 receptor complexes. IL-4 and IL-13 are key cytokines in driving type 2 inflammation, a dominant and… read more here.
Keywords: dupilumab review; severe asthma; asthma; review moderate ... See more keywords