Factors Associated With Severe COVID-19 Among Vaccinated Adults Treated in US Veterans Affairs Hospitals
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.40037
Abstract: Key Points Question What are risk factors for severe breakthrough SARS-CoV-2 infections among vaccinated individuals? Findings In this cohort study of 110 760 vaccinated US veterans, increasing age was most strongly associated with severe disease, with… read more here.
Keywords: severe covid; factors associated; risk; associated severe ... See more keywords
Efficacy and Safety of Anakinra Plus Standard of Care for Patients With Severe COVID-19
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DOI: 10.1001/jamanetworkopen.2023.7243
Abstract: Key Points Question Is the use of anakinra plus the standard of care effective compared with the standard of care alone in reducing the probability of requiring mechanical ventilation among patients with severe COVID-19 pneumonia?… read more here.
Keywords: standard care; severe covid; plus standard; patients severe ... See more keywords
Systemic redox imbalance in severe COVID‐19 patients
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DOI: 10.1002/cbf.3735
Abstract: The aim of this study was to evaluate the systemic redox state and inflammatory markers in intensive care unit (ICU) or non‐ICU severe COVID‐19 patients during the hospitalization period. Blood samples were collected at hospital… read more here.
Keywords: covid patients; severe covid; icu covid; covid ... See more keywords
Increased B‐cell activity with consumption of activated monocytes in severe COVID‐19 patients
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202049163
Abstract: The pathogenesis of autoimmune complications triggered by SARS‐CoV2 has not been completely elucidated. Here, we performed an analysis of the cellular immune status, cell ratios, and monocyte populations of patients with COVID‐19 treated in the… read more here.
Keywords: increased cell; cohort; cell activity; cell ... See more keywords
Can steroids reverse the severe COVID‐19 induced ‘cytokine storm’?
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DOI: 10.1002/jmv.26165
Abstract: Severe coronavirus disease (COVID‐19) is characterized by an excessive proinflammatory cytokine storm, resulting in acute lung injury and development of acute respiratory distress syndrome (ARDS). The role of corticosteroids is controversial in severe COVID‐19 pneumonia… read more here.
Keywords: steroids reverse; cytokine storm; covid; days median ... See more keywords
SARS‐CoV‐2 was found in the bile juice from a patient with severe COVID‐19
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Virology"
DOI: 10.1002/jmv.26169
Abstract: Abstract SARS‐CoV‐2 has infected over 170,000 people worldwide and was associated with substantial mortality. Previous studies have reported that the SARS‐CoV‐2 could be detected in sputum, faeces, urine and other specimens from COVID‐19 patients. In… read more here.
Keywords: found bile; bile juice; patient severe; sars cov ... See more keywords
Investigation of plasma exchange and hemoperfusion effects and complications for the treatment of patients with severe COVID‐19 (SARS‐CoV‐2) disease: A systematic scoping review
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27182
Abstract: Some previous studies suggested that the plasma exchange (PE) and hemoperfusion (HP) played a cardinal role in the treatment of severe coronavirus disease 2019 (COVID‐19) cases by diminishing the cytokine storm. This study aimed to… read more here.
Keywords: patients severe; treatment; plasma exchange; systematic scoping ... See more keywords
FURIN gene variants (rs6224/rs4702) as potential markers of death and cardiovascular traits in severe COVID‐19
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27748
Abstract: Furin is a protease that plays a key role in the infection cycle of SARS‐CoV‐2 by cleaving the viral proteins during the virus particle assembly. In addition, Furin regulates several physiological processes related to cardio‐metabolic… read more here.
Keywords: severe covid; rs6224 rs4702; death; furin gene ... See more keywords
Inactivated vaccines prevent severe COVID-19 in patients infected with the Delta variant: a comparative study of the Delta and Alpha variants from China.
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DOI: 10.1002/jmv.27759
Abstract: BACKGROUND The Delta variant has gradually replaced the Alpha variant as the major strain of SARS-COV-2 infection worldwide. METHODS We extracted the clinical characteristics and outcomes information about 381 hospitalized patients infected with Delta variant… read more here.
Keywords: infected delta; delta variant; variant; patients infected ... See more keywords
COVID‐19 and platelet traits: A bidirectional Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27920
Abstract: This study aimed to evaluate the host genetic liability of coronavirus disease 2019 (covid‐19) with platelet traits using the Mendelian randomization (MR) approach. We conducted a bidirectional two‐sample MR using summary statistics from the largest… read more here.
Keywords: severe covid; covid platelet; mendelian randomization; platelet traits ... See more keywords
Transcriptome‐wide summary data‐based Mendelian randomization analysis reveals 38 novel genes associated with severe COVID‐19
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28162
Abstract: Severe COVID‐19 has a poor prognosis, while the genetic mechanism underlying severe COVID‐19 remains largely unknown. We aimed to identify genes that are potentially causally associated with severe COVID‐19. We conducted a summary data‐based Mendelian… read more here.
Keywords: severe covid; covid; analysis; associated severe ... See more keywords