Advances in Our Understanding of the Interaction of Drugs with T-cells: Implications for the Discovery of Biomarkers in Severe Cutaneous Drug Reactions.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.1c00434
Abstract: Drugs can activate different cells of the immune system and initiate an immune response that can lead to life-threatening diseases collectively known as severe cutaneous adverse reactions (SCARs). Antibiotics, anticonvulsants, and antiretrovirals are involved in… read more here.
Keywords: understanding interaction; interaction drugs; severe cutaneous; drug ... See more keywords
A retrospective single-centre case series of paediatric blistering severe cutaneous adverse reactions (SCARs): evaluation using new diagnostic classification confirms value of British Association of Dermatologists' guidelines.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and experimental dermatology"
DOI: 10.1093/ced/llad014
Abstract: Stevens-Johnson syndrome and toxic epidermonecrolysis are especially challenging to diagnose and manage in paediatric population given their rarity, more frequent infectious triggers and lack of randomized controlled trials to guide management. This retrospective case series… read more here.
Keywords: case series; paediatric blistering; series paediatric; cutaneous adverse ... See more keywords
Cetuximab severe cutaneous toxicity… a gateway for bacteremia: case report.
Sign Up to like & getrecommendations! Published in 2022 at "Anti-cancer drugs"
DOI: 10.1097/cad.0000000000001312
Abstract: EGFR inhibitors used in the treatment of metastatic wild-RAS colorectal cancer in combination with chemotherapy are associated with dermatologic side events that are low grade in most cases. We report a case of severe cutaneous… read more here.
Keywords: cetuximab; cutaneous toxicity; toxicity; report ... See more keywords
Potential role of regulatory DNA variants in modifying the risk of severe cutaneous reactions induced by aromatic anti-seizure medications.
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DOI: 10.1111/epi.17182
Abstract: OBJECTIVE Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions. Antiseizure medications (ASMs) with aromatic ring structure, including carbamazepine, are among the most common culprits. Screening for human leukocyte antigen… read more here.
Keywords: hla; risk; analysis; regulatory dna ... See more keywords
A slowly developed severe cutaneous adverse reaction to idelalisib
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.14700
Abstract: Intracellular signal mediator phosphatidylinositol-3-kinase (PIK3K) –δ, an isoform of PIK3K, is expressed in hematopoietic cells especially in lymphoid lineage 1. Idelalisib is a novel PIK3K-δ targeted kinase inhibitor which is approved for relapsed follicular B-cell… read more here.
Keywords: adverse reaction; severe cutaneous; slowly developed; idelalisib ... See more keywords
Clinical and pathogenic aspects of the severe cutaneous adverse reaction epidermal necrolysis (EN)
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.16339
Abstract: The severe cutaneous adverse reaction epidermal necrolysis (EN) which includes toxic epidermal necrolysis and the milder Stevens‐Johnson syndrome is characterized by epidermal loss due to massive keratinocyte apoptosis and/or necroptosis. EN is often caused by… read more here.
Keywords: adverse reaction; severe cutaneous; reaction epidermal; necrolysis ... See more keywords
Drug‐induced liver injury associated with severe cutaneous adverse drug reactions: A nationwide study in Taiwan
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DOI: 10.1111/liv.14990
Abstract: Severe cutaneous adverse drug reactions (SCARs) including Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS) and acute generalized exanthematous pustulosis (AGEP) are high‐mortality adverse drug reactions. The risk… read more here.
Keywords: severe cutaneous; drug reactions; cutaneous adverse; drug induced ... See more keywords
Study protocol: Australasian Registry of Severe Cutaneous Adverse Reactions (AUS-SCAR)
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-055906
Abstract: Introduction Severe cutaneous adverse reactions (SCAR) are a group of T cell-mediated hypersensitivities associated with significant morbidity, mortality and hospital costs. Clinical phenotypes include Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia… read more here.
Keywords: adverse reactions; registry; cutaneous adverse; severe cutaneous ... See more keywords
Genetics of Severe Cutaneous Adverse Reactions
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DOI: 10.3389/fmed.2021.652091
Abstract: Severe cutaneous adverse reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS) are T cells-mediated life-threatening immune reactions, most commonly induced by drug. The last… read more here.
Keywords: severe cutaneous; genetics; cutaneous adverse; adverse reactions ... See more keywords
Pharmacogenetic Testing for Prevention of Severe Cutaneous Adverse Drug Reactions
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DOI: 10.3389/fphar.2020.00969
Abstract: Severe cutaneous adverse reactions (SCAR), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS), are idiosyncratic and unpredictable drug-hypersensitivity reactions with a high-mortality rate ranging from… read more here.
Keywords: severe cutaneous; cutaneous adverse; prevention severe; drug ... See more keywords
Drug-Induced Severe Cutaneous Adverse Reactions: Insights Into Clinical Presentation, Immunopathogenesis, Diagnostic Methods, Treatment, and Pharmacogenomics
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.832048
Abstract: SCARs are rare and life-threatening hypersensitivity reactions. In general, the increased duration of hospital stays and the associated cost burden are common issues, and in the worst-case scenario, they can result in mortality. SCARs are… read more here.
Keywords: drug induced; induced severe; presentation; cutaneous adverse ... See more keywords