A polygenic biomarker to identify patients with severe hypercholesterolemia of polygenic origin
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DOI: 10.1002/mgg3.1248
Abstract: Severe hypercholesterolemia (HC, LDL‐C > 4.9 mmol/L) affects over 30 million people worldwide. In this study, we validated a new polygenic risk score (PRS) for LDL‐C. read more here.
Keywords: patients severe; hypercholesterolemia; polygenic biomarker; biomarker identify ... See more keywords
Microvascular Function and Endothelial Progenitor Cells in Patients with Severe Hypercholesterolemia and the Familial Hypercholesterolemia Phenotype
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DOI: 10.1159/000470829
Abstract: Objective: To evaluate endothelial progenitor cells (EPCs) and systemic microvascular function in patients with severe hypercholesterolemia, comparing patients with the definite familial hypercholesterolemia (FH) phenotype (DFH) or probable/possible FH phenotype (PFH). There is a large… read more here.
Keywords: phenotype; progenitor cells; hypercholesterolemia; microvascular function ... See more keywords
Abstract 14124: Characteristics and Outcomes of Severe Hypercholesterolemia in Patients With St-segment Elevated Myocardial Infarction
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DOI: 10.1161/circ.142.suppl_3.14124
Abstract: Background: Patients with severe hypercholesterolemia (SH) are at increased risk of developing cardiovascular disease. The aim of this study was to examine the characteristics and outcomes of ST-se... read more here.
Keywords: characteristics outcomes; 14124 characteristics; outcomes severe; abstract 14124 ... See more keywords
Abstract 15830: Uncontrolled and Undertreated Cholesterol in Patients With Severe Hypercholesterolemia at a Large Healthcare System
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DOI: 10.1161/circ.142.suppl_3.15830
Abstract: Introduction: Patients with phenotypic severe hypercholesterolemia (SH) (low-density lipoprotein-cholesterol (LDL-c) ≥ 190 mg/dL), should have at least 50% LDL-c lowering by treatment with a maximally tolerated statin to goal LDL-c 250 mg/dL (32.8% not currently… read more here.
Keywords: 15830 uncontrolled; abstract 15830; cholesterol; ldl 100 ... See more keywords