Effectiveness of a Novel ω-3 Krill Oil Agent in Patients With Severe Hypertriglyceridemia: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2021.41898
Abstract: Importance Intense interest exists in novel ω-3 formulations with high bioavailability to reduce blood triglyceride (TG) levels. Objective To determine the phase 3 efficacy and safety of a naturally derived krill oil with eicosapentaenoic acid… read more here.
Keywords: krill oil; severe hypertriglyceridemia; mean treatment; cholesterol ... See more keywords
Efficacy and cost of double filtration plasmapheresis in severe hypertriglyceridemia-induced pancreatitis: A retrospective observational study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of clinical apheresis"
DOI: 10.1002/jca.22032
Abstract: BACKGROUND The value of double filtration plasmapheresis (DFPP) in severe hypertriglyceridemia-induced pancreatitis (sHTGP) is controversial. This study aimed to investigate the efficacy of DFPP on clinical outcomes in patients with sHTGP and the costs associated… read more here.
Keywords: severe hypertriglyceridemia; hypertriglyceridemia induced; filtration plasmapheresis; double filtration ... See more keywords
New rare genetic variants of LMF1 gene identified in severe hypertriglyceridemia.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of clinical lipidology"
DOI: 10.1016/j.jacl.2018.06.018
Abstract: BACKGROUND The LMF1 (lipase maturation factor 1) gene encodes a protein involved in lipoprotein lipase and hepatic lipase maturation. Homozygous mutations in LMF1 leading to severe hypertriglyceridemia (SHTG) are rare in the literature. A few… read more here.
Keywords: severe hypertriglyceridemia; lpl activity; gene; lmf1 ... See more keywords
Involvement of a homozygous exon 6 deletion of LMF1 gene in intermittent severe hypertriglyceridemia.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of clinical lipidology"
DOI: 10.1016/j.jacl.2020.09.004
Abstract: Severe hypertriglyceridemia (HTG), characterized by triglycerides (TG) permanently over 10 mmol/L, may correspond to familial chylomicronemia syndrome (FCS), a rare disorder. However, hypertriglyceridemic patients more often present multifactorial chylomicronemia syndrome (MCS), characterized by highly variable TG.… read more here.
Keywords: severe hypertriglyceridemia; intermittent severe; lmf1 gene; deletion ... See more keywords
Genetic and functional studies of the LMF1 gene in Thai patients with severe hypertriglyceridemia
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics and Metabolism Reports"
DOI: 10.1016/j.ymgmr.2020.100576
Abstract: Severe hypertriglyceridemia (HTG) due to chylomicronemia is associated with acute pancreatitis and is related to genetic disturbances in several proteins involved in triglyceride (TG) metabolism. Lipase maturation factor 1 (LMF1) is a protein essential for… read more here.
Keywords: severe hypertriglyceridemia; genetic functional; lmf1 gene; severe htg ... See more keywords
Evaluation of efficacy and safety of antisense inhibition of apolipoprotein C-III with volanesorsen in patients with severe hypertriglyceridemia
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2020.1787380
Abstract: ABSTRACT Introduction Severe hypertriglyceridemia (sHTG) is a complex disorder of lipid metabolism characterized by plasma levels of triglyceride (TG) greater than 885 mg/dl (>10 mmol/L). The treatment of sHTG syndromes is challenging because conventional treatments… read more here.
Keywords: severe hypertriglyceridemia; efficacy safety; treatment; safety ... See more keywords
Eruptive xanthoma associated with severe hypertriglyceridemia and poorly controlled type 1 diabetes mellitus
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Community Hospital Internal Medicine Perspectives"
DOI: 10.1080/20009666.2019.1650591
Abstract: ABSTRACT Eruptive xanthoma is characterized by yellowish skin papules encircled by an erythematous halo and associated with severe hypertriglyceridemia above 2,000 mg/dl. Hypertriglyceridemia can be caused by primary genetic mutations, secondary causes, such as uncontrolled… read more here.
Keywords: xanthoma; severe hypertriglyceridemia; diabetes mellitus; eruptive xanthoma ... See more keywords
Acute starvation ketoacidosis in pregnancy with severe hypertriglyceridemia
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000010609
Abstract: Rationale: Pregnant women are more prone to ketosis due to the relative insulin resistance, accelerated lipolysis and increased free fatty acids. Patient concerns: We report a pregnant woman with hyperlipidemia, who experienced severe metabolic acidosis… read more here.
Keywords: severe hypertriglyceridemia; pregnancy severe; starvation; starvation ketoacidosis ... See more keywords
Severe hypertriglyceridemia in an infant on chronic hemodialysis
Sign Up to like & getrecommendations! Published in 2022 at "Hemodialysis International"
DOI: 10.1111/hdi.13049
Abstract: Severe hyperlipidemia is a risk factor for cardiovascular disease. Children with chronic kidney disease and end stage renal disease are at risk for development of hyperlipidemia. In this report, we describe a 7‐month‐old male infant… read more here.
Keywords: hypertriglyceridemia infant; hemodialysis; severe hypertriglyceridemia; infant chronic ... See more keywords
Analysis of Intravenous Insulin Dosing Requirements for Treatment of Severe Hypertriglyceridemia
Sign Up to like & getrecommendations! Published in 2022 at "Hospital Pharmacy"
DOI: 10.1177/00185787221126339
Abstract: Purpose: Insulin infusion therapy is commonly utilized for treatment of severe hypertriglyceridemia, however, data supporting a standardized dosing approach is lacking. This study aimed to determine the average initial insulin dose utilized for treatment of… read more here.
Keywords: severe hypertriglyceridemia; hypertriglyceridemia; treatment severe; intravenous insulin ... See more keywords
Marked effects of novel selective peroxisome proliferator-activated receptor α modulator, pemafibrate in severe hypertriglyceridemia: preliminary report
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular Diabetology"
DOI: 10.1186/s12933-020-01172-8
Abstract: Background Currently available treatments have only been partly successful in patients with severe hypertriglyceridemia, including those with high serum triglycerides above 1,000 mg/dL (11.3 mmol/L), who often suffer from acute pancreatitis. Pemafibrate is a novel selective peroxisome… read more here.
Keywords: mmol; severe hypertriglyceridemia; selective peroxisome; pemafibrate ... See more keywords