Severe hypoxia increases expression of ATM and DNA-PKcs and it increases their activities through Src and AMPK signaling pathways.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.09.068
Abstract: BACKGROUND Solid tumors often contain hypoxic regions because an abnormal and inefficient tumor vasculature is unable to supply sufficient oxygen. Tissue hypoxia is generally defined as a low oxygen concentration of less than 2%. It… read more here.
Keywords: dna pkcs; severe hypoxia; atm dna;
Involvement of JNK/FOXO1 pathway in apoptosis induced by severe hypoxia in porcine granulosa cells.
Sign Up to like & getrecommendations! Published in 2020 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2020.05.019
Abstract: In ovaries, follicles undergo a periodic process of degeneration, namely atresia, during each stage of development. Granulosa cell (GC) apoptosis is believed as the hallmark of follicular atresia. The avascular environment within the granulosa compartment… read more here.
Keywords: apoptosis; porcine gcs; severe hypoxia; hypoxia ... See more keywords
Use of cardiac troponin I (cTnI) levels to diagnose severe hypoxia and myocardial injury induced by perinatal asphyxia in neonatal dogs.
Sign Up to like & getrecommendations! Published in 2021 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2021.12.027
Abstract: Prolonged perinatal asphyxia and subsequent severe hypoxia are the main causes of mortality in neonatal dogs in the first days of life. In medicine, specific cardiac biochemical markers, such as troponin I, are used to… read more here.
Keywords: injury; ctni levels; severe hypoxia; ctni ... See more keywords
Cognitive function during exercise under severe hypoxia
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10332-y
Abstract: Acute exercise has been demonstrated to improve cognitive function. In contrast, severe hypoxia can impair cognitive function. Hence, cognitive function during exercise under severe hypoxia may be determined by the balance between the beneficial effects… read more here.
Keywords: function exercise; severe hypoxia; cognitive function; hypoxia ... See more keywords
Improved survival following ward-based non-invasive pressure support for severe hypoxia in a cohort of frail patients with COVID-19: retrospective analysis from a UK teaching hospital
Sign Up to like & getrecommendations! Published in 2020 at "BMJ Open Respiratory Research"
DOI: 10.1136/bmjresp-2020-000621
Abstract: Since the outbreak of COVID-19 in China in December 2019, a pandemic has rapidly developed on a scale that has overwhelmed health services in a number of countries. COVID-19 has the potential to lead to… read more here.
Keywords: based non; non invasive; severe hypoxia; ward based ... See more keywords
Severe hypoxia selects hematopoietic progenitors with stem cell potential from primary Myelodysplastic syndrome bone marrow cell cultures
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.24302
Abstract: Myelodysplastic Syndromes (MDS) are clonal neoplasms where stem/progenitor cells endowed with self-renewal and capable of perpetuating the disease have been demonstrated. It is known that oxygen tension plays a key role in driving normal hematopoiesis… read more here.
Keywords: stem cell; cell; severe hypoxia; cell potential ... See more keywords
Historical Shifts in Benthic Infaunal Diversity in the Northern Gulf of Mexico since the Appearance of Seasonally Severe Hypoxia
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DOI: 10.3390/d12020049
Abstract: Severe and persistent bottom-water hypoxia (≤2 mg O2 L−1) occurs on the Louisiana/Texas continental shelf from mid-May through mid-September over a large area (up to 23,000 km2 in mid-summer). Benthic infauna are less mobile than… read more here.
Keywords: diversity; deposit feeders; benthic infaunal; severe hypoxia ... See more keywords