Leukocyte Adhesion Deficiency-I (LAD-I): A Comprehensive Review of Published Cases
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DOI: 10.1182/blood.v130.suppl_1.4821.4821
Abstract: LAD-I is a rare disorder of leukocyte adhesion, resulting from ITGB2 gene mutations encoding for the Beta-2 Integrin component CD18. CD18 deficiencies prevent integrin dimerization and endothelial leukocyte adhesion, essential for extravasation and antimicrobial activity.… read more here.
Keywords: lad; cd18; hsct; leukocyte adhesion ... See more keywords