Clinical features and haematological parameters among malaria patients in Mangaluru city area in the southwestern coastal region of India
Sign Up to like & getrecommendations! Published in 2019 at "Parasitology Research"
DOI: 10.1007/s00436-019-06540-2
Abstract: The aim of this study was to assess the clinical profile, severity and complications of patients suffering from malaria in Mangaluru, a southwestern coastal city in India. A total of 579 patients, who were treated… read more here.
Keywords: recruited study; clinical features; city; southwestern coastal ... See more keywords
Severe malaria presenting to the ED: A collaborative approach utilizing exchange transfusion and artesunate
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Emergency Medicine"
DOI: 10.1016/j.ajem.2018.03.023
Abstract: Abstract We describe the case of a previously healthy 33 year‐old male pilot recently arrived to the United States from Africa. The patient presented to our ED febrile and disoriented, with projectile coffee‐ground emesis. He… read more here.
Keywords: medicine; malaria presenting; collaborative approach; presenting collaborative ... See more keywords
Neuropsychological benefits of computerized cognitive rehabilitation training in Ugandan children surviving severe malaria: A randomized controlled trial
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2018.03.002
Abstract: BACKGROUND Computerized cognitive rehabilitation training (CCRT) may be beneficial for alleviating persisting neurocognitive deficits in Ugandan severe malaria survivors. We completed a randomized controlled trial of CCRT for both severe malaria and non-malaria cohorts of… read more here.
Keywords: malaria children; limited ccrt; training; ccrt ... See more keywords
Comparative Analysis of Host Metabolic Alterations in Murine Malaria Models with Uncomplicated or Severe Malaria.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00123
Abstract: Malaria varies in severity, with complications ranging from uncomplicated to severe malaria. Severe malaria could be attributed to peripheral hyperparasitemia or cerebral malaria. The metabolic interactions between the host and Plasmodium species are yet to… read more here.
Keywords: uncomplicated severe; severe malaria; host metabolic; cerebral malaria ... See more keywords
SC83288 is a clinical development candidate for the treatment of severe malaria
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14193
Abstract: Severe malaria is a life-threatening complication of an infection with the protozoan parasite Plasmodium falciparum, which requires immediate treatment. Safety and efficacy concerns with currently used drugs accentuate the need for new chemotherapeutic options against… read more here.
Keywords: clinical development; treatment; severe malaria; development candidate ... See more keywords
The spectrum of clinical biomarkers in severe malaria and new avenues for exploration
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2056966
Abstract: ABSTRACT Globally, malaria is a public health concern, with severe malaria (SM) contributing a major share of the disease burden in malaria endemic countries. In this context, identification and validation of SM biomarkers are essential… read more here.
Keywords: clinical biomarkers; biomarkers severe; severe malaria; validation biomarkers ... See more keywords
Tumour necrosis factor-α as a prognostic biomarker of severe malaria: a systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of travel medicine"
DOI: 10.1093/jtm/taac053
Abstract: BACKGROUND Tumour necrosis factor-alpha (TNF-α) levels are reportedly altered during malaria. In this systematic review and meta-analysis, we aimed to collect and compare data on TNF-α levels between patients with malaria of varying severity and… read more here.
Keywords: review meta; meta analysis; tnf levels; severe malaria ... See more keywords
Acute Kidney Injury in Children with Severe Malaria Is Common and Associated with Adverse Hospital Outcomes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of tropical pediatrics"
DOI: 10.1093/tropej/fmz057
Abstract: BACKGROUND The prevalence of acute kidney injury (AKI) in children with severe malaria in sub-Saharan African may have been underestimated. The study aimed to determine the prevalence of AKI in children with severe malaria and… read more here.
Keywords: kidney injury; children severe; severe malaria; acute kidney ... See more keywords
WHO should accelerate, not stall, rectal artesunate deployment for pre-referral treatment of severe malaria.
Sign Up to like & getrecommendations! Published in 2023 at "Transactions of the Royal Society of Tropical Medicine and Hygiene"
DOI: 10.1093/trstmh/trad002
Abstract: The recent World Health Organization moratorium on rectal artesunate (RAS) for pre-referral treatment of severe childhood malaria is costing young lives. The decision was based on disappointing findings from a large observational study that provided… read more here.
Keywords: severe malaria; referral treatment; treatment severe; pre referral ... See more keywords
Endothelial Activation, Acute Kidney Injury, and Cognitive Impairment in Pediatric Severe Malaria
Sign Up to like & getrecommendations! Published in 2020 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000004469
Abstract: Supplemental Digital Content is available in the text. Objectives: Evaluate the relationship between endothelial activation, malaria complications, and long-term cognitive outcomes in severe malaria survivors. Design: Prospectively cohort study of children with cerebral malaria, severe… read more here.
Keywords: kidney injury; endothelial activation; severe malaria; acute kidney ... See more keywords
Assessment of Myocardial Function and Injury by Echocardiography and Cardiac Biomarkers in African Children With Severe Plasmodium falciparum Malaria*
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Critical Care Medicine"
DOI: 10.1097/pcc.0000000000001411
Abstract: Objectives: Perturbed hemodynamic function complicates severe malaria. The Fluid Expansion as Supportive Therapy trial demonstrated that fluid resuscitation, involving children with severe malaria, was associated with increased mortality, primarily due to cardiovascular collapse, suggesting that… read more here.
Keywords: cardiac index; malarial anemia; children severe; severe malaria ... See more keywords