Effect of Severe Renal Impairment on Pharmacokinetics, Safety, and Tolerability of ACT‐1014‐6470, a Novel Oral Complement Factor 5a Receptor 1 Antagonist
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DOI: 10.1002/cpdd.1184
Abstract: The aim of this study was to examine the safety and the effect of severe renal impairment (RI) on the pharmacokinetics of ACT‐1014‐6470, a novel oral complement factor 5a receptor 1 antagonist. A phase 1… read more here.
Keywords: safety; effect severe; 1014 6470; act 1014 ... See more keywords
Targeted next‐generation sequencing in a large series of fetuses with severe renal diseases
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24324
Abstract: We report the screening of a large panel of genes in a series of 100 fetuses (98 families) affected with severe renal defects. Causative variants were identified in 22% of cases, greatly improving genetic counseling.… read more here.
Keywords: series; next generation; targeted next; severe renal ... See more keywords
Effect of severe renal impairment on the pharmacokinetics of brigatinib
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DOI: 10.1007/s10637-021-01095-5
Abstract: Background Brigatinib, a next-generation anaplastic lymphoma kinase (ALK) inhibitor, targets activated, mutant forms of ALK and overcomes mechanisms of resistance to the ALK inhibitors crizotinib, ceritinib, and alectinib. Brigatinib is approved in multiple countries for… read more here.
Keywords: patients severe; severe renal; brigatinib; impairment ... See more keywords
Early post-traumatic renal vascular hypertension a rare complication of severe renal trauma
Sign Up to like & getrecommendations! Published in 2020 at "Urology Case Reports"
DOI: 10.1016/j.eucr.2020.101341
Abstract: Severe renal trauma is a particular entity, although rare, but most often involves the risk of short-term death from hemorrhagic shock and long-term death from infectious complications or secondary renal dysfunction, exceptionally post-renal vascular hypertension.… read more here.
Keywords: renal trauma; renal vascular; severe renal; early post ... See more keywords
Pharmacokinetics of Cabotegravir in Subjects with Severe Renal Impairment
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DOI: 10.1093/ofid/ofx163.1085
Abstract: Abstract Background Cabotegravir (CAB) is an integrase inhibitor in phase 3 clinical trials for the treatment and prevention of HIV. CAB undergoes glucuronidation via UGT1A1 with read more here.
Keywords: employee; severe renal; subjects severe; cab ... See more keywords
Evaluation of the management of severe trauma kidney injury and long-term renal function in children
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000001854
Abstract: BACKGROUND To evaluate the management and long-term renal function with DMSA scintigraphy in pediatric severe traumatic kidney injury grade IV and V at the trauma center of Grenoble Teaching Hospital. METHODS This is a single-center… read more here.
Keywords: renal trauma; severe renal; trauma; function ... See more keywords
Nemonoxacin Dosage Adjustment in Patients with Severe Renal Impairment Based on Population Pharmacokinetic and Pharmacodynamic Analysis.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.14881
Abstract: AIMS To optimize the dosing regimen in patients with severe renal impairment based on population pharmacokinetic/pharmacodynamic (PPK/PD) analysis. METHODS The pharmacokinetics and safety of nemonoxacin was evaluated in a single-dose, open-label, nonrandomized, parallel-group study after… read more here.
Keywords: patients severe; based population; severe renal; impairment based ... See more keywords
IgA vasculitis with severe renal manifestation
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DOI: 10.1136/bcr-2021-248686
Abstract: IgA vasculitis is a rare systemic vasculitis in adults, frequently more severe than in paediatric age. It manifests with cutaneous, articular, gastrointestinal and renal involvement. We present a case of a man in his 40s… read more here.
Keywords: vasculitis; vasculitis severe; case; severe renal ... See more keywords
Ticagrelor versus Clopidogrel in Patients with Severe Renal Insufficiency Undergoing PCI for Acute Coronary Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Interventional Cardiology"
DOI: 10.1155/2022/6476777
Abstract: Background Current guidelines recommend the use of potent antiplatelet agents in patients undergoing percutaneous coronary intervention (PCI) following an acute coronary syndrome (ACS). However, data about optimal platelet inhibition in severe renal insufficiency patients are… read more here.
Keywords: ticagrelor; acute coronary; clopidogrel; severe renal ... See more keywords
Rituximab in relapsing and de novo MPO ANCA-associated vasculitis with severe renal involvement: a case series
Sign Up to like & getrecommendations! Published in 2019 at "BMC Nephrology"
DOI: 10.1186/s12882-019-1350-x
Abstract: BackgroundAntineutrophil cytoplasmic antibody associated vasculitis (AAV) is a group of diseases associated in most cases with the presence of anti-neutrophil cytoplasmic antibodies (ANCAs). Rituximab- based remission induction has been proven effective in ANCA associated vasculitis… read more here.
Keywords: rituximab; vasculitis; severe renal; renal involvement ... See more keywords
[Atypical presentation of a congenital metastatic neuroblastoma with severe renal impact: case report].
Sign Up to like & getrecommendations! Published in 2021 at "Archivos argentinos de pediatria"
DOI: 10.5546/aap.2021.e626
Abstract: Neuroblastoma is a neural crest-derived tumor and the most common malignant tumor in neonates. Its clinical presentation can be quite variable. In some cases, it presents as an aggressive metastatic disease whilst in others it… read more here.
Keywords: atypical presentation; presentation; severe renal; presentation congenital ... See more keywords