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   Articles with "severe renal" as a keyword



Effect of Severe Renal Impairment on Pharmacokinetics, Safety, and Tolerability of ACT‐1014‐6470, a Novel Oral Complement Factor 5a Receptor 1 Antagonist

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recommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.1184

Abstract: The aim of this study was to examine the safety and the effect of severe renal impairment (RI) on the pharmacokinetics of ACT‐1014‐6470, a novel oral complement factor 5a receptor 1 antagonist. A phase 1… read more here.

Keywords: safety; effect severe; 1014 6470; act 1014 ... See more keywords

Targeted next‐generation sequencing in a large series of fetuses with severe renal diseases

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recommendations! Published in 2022 at "Human Mutation"

DOI: 10.1002/humu.24324

Abstract: We report the screening of a large panel of genes in a series of 100 fetuses (98 families) affected with severe renal defects. Causative variants were identified in 22% of cases, greatly improving genetic counseling.… read more here.

Keywords: series; next generation; targeted next; severe renal ... See more keywords
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Effect of severe renal impairment on the pharmacokinetics of brigatinib

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recommendations! Published in 2021 at "Investigational New Drugs"

DOI: 10.1007/s10637-021-01095-5

Abstract: Background Brigatinib, a next-generation anaplastic lymphoma kinase (ALK) inhibitor, targets activated, mutant forms of ALK and overcomes mechanisms of resistance to the ALK inhibitors crizotinib, ceritinib, and alectinib. Brigatinib is approved in multiple countries for… read more here.

Keywords: patients severe; severe renal; brigatinib; impairment ... See more keywords
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Early post-traumatic renal vascular hypertension a rare complication of severe renal trauma

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recommendations! Published in 2020 at "Urology Case Reports"

DOI: 10.1016/j.eucr.2020.101341

Abstract: Severe renal trauma is a particular entity, although rare, but most often involves the risk of short-term death from hemorrhagic shock and long-term death from infectious complications or secondary renal dysfunction, exceptionally post-renal vascular hypertension.… read more here.

Keywords: renal trauma; renal vascular; severe renal; early post ... See more keywords

Pharmacokinetics of Cabotegravir in Subjects with Severe Renal Impairment

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recommendations! Published in 2017 at "Open Forum Infectious Diseases"

DOI: 10.1093/ofid/ofx163.1085

Abstract: Abstract Background Cabotegravir (CAB) is an integrase inhibitor in phase 3 clinical trials for the treatment and prevention of HIV. CAB undergoes glucuronidation via UGT1A1 with read more here.

Keywords: employee; severe renal; subjects severe; cab ... See more keywords

Evaluation of the management of severe trauma kidney injury and long-term renal function in children

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recommendations! Published in 2018 at "Journal of Trauma and Acute Care Surgery"

DOI: 10.1097/ta.0000000000001854

Abstract: BACKGROUND To evaluate the management and long-term renal function with DMSA scintigraphy in pediatric severe traumatic kidney injury grade IV and V at the trauma center of Grenoble Teaching Hospital. METHODS This is a single-center… read more here.

Keywords: renal trauma; severe renal; trauma; function ... See more keywords
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Nemonoxacin Dosage Adjustment in Patients with Severe Renal Impairment Based on Population Pharmacokinetic and Pharmacodynamic Analysis.

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recommendations! Published in 2021 at "British journal of clinical pharmacology"

DOI: 10.1111/bcp.14881

Abstract: AIMS To optimize the dosing regimen in patients with severe renal impairment based on population pharmacokinetic/pharmacodynamic (PPK/PD) analysis. METHODS The pharmacokinetics and safety of nemonoxacin was evaluated in a single-dose, open-label, nonrandomized, parallel-group study after… read more here.

Keywords: patients severe; based population; severe renal; impairment based ... See more keywords

The effect of severe renal impairment on the pharmacokinetics, safety and tolerability of mitiperstat

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recommendations! Published in 2024 at "British Journal of Clinical Pharmacology"

DOI: 10.1111/bcp.16205

Abstract: Mitiperstat is a novel, highly potent myeloperoxidase inhibitor being evaluated in patients with cardio‐metabolic disease (phase 2). These patients often have impaired renal function, which may affect mitiperstat pharmacokinetics. This study assessed mitiperstat pharmacokinetics, safety… read more here.

Keywords: renal impairment; pharmacokinetics safety; safety tolerability; severe renal ... See more keywords

IgA vasculitis with severe renal manifestation

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recommendations! Published in 2022 at "BMJ Case Reports"

DOI: 10.1136/bcr-2021-248686

Abstract: IgA vasculitis is a rare systemic vasculitis in adults, frequently more severe than in paediatric age. It manifests with cutaneous, articular, gastrointestinal and renal involvement. We present a case of a man in his 40s… read more here.

Keywords: vasculitis; vasculitis severe; case; severe renal ... See more keywords

Ticagrelor versus Clopidogrel in Patients with Severe Renal Insufficiency Undergoing PCI for Acute Coronary Syndrome

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recommendations! Published in 2022 at "Journal of Interventional Cardiology"

DOI: 10.1155/2022/6476777

Abstract: Background Current guidelines recommend the use of potent antiplatelet agents in patients undergoing percutaneous coronary intervention (PCI) following an acute coronary syndrome (ACS). However, data about optimal platelet inhibition in severe renal insufficiency patients are… read more here.

Keywords: ticagrelor; acute coronary; clopidogrel; severe renal ... See more keywords

Current Trends of Severe Renal Impairment in Newly Diagnosed Multiple Myeloma: A Single-Center Experience in a Low Socio-Economic Population

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-208770

Abstract: Background: Recent advancements in multiple myeloma (MM) diagnosis and treatment significantly improved patients' survival and quality of life. Severe Renal Impairment (RI) remains a significant challenge in newly diagnosed MM (NDMM), complicating treatment and affecting… read more here.

Keywords: diagnosis; multiple myeloma; severe renal; renal impairment ... See more keywords