Association Between Implementation of the Severe Sepsis and Septic Shock Early Management Bundle Performance Measure and Outcomes in Patients With Suspected Sepsis in US Hospitals
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.38596
Abstract: Key Points Question Was implementation of the CMS Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) in October 2015 associated with improvements in sepsis-associated mortality? Findings In this cohort study of 117 510 adult patients… read more here.
Keywords: sepsis septic; sepsis; severe sepsis; shock early ... See more keywords
Association of do-not-resuscitate order and survival in patients with severe sepsis and/or septic shock
Sign Up to like & getrecommendations! Published in 2017 at "Intensive Care Medicine"
DOI: 10.1007/s00134-017-4690-7
Abstract: Dear Editor, Do-not-resuscitate (DNR) orders have been widely used for critically ill patients [1]. However, their impact on survival outcome is largely unknown for patients with severe sepsis and/or septic shock. The aim of the… read more here.
Keywords: dnr; septic shock; sepsis septic; severe sepsis ... See more keywords
Serum caspase-cleaved cytokeratin-18 fragment as a prognostic biomarker in hematological patients with febrile neutropenia
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-021-00734-8
Abstract: The study aim was to determine the benefit of the measurement of serum caspase-cleaved cytokeratin-18 (CK-18) fragment as a prognostic marker of febrile neutropenia (FN) in hematological patients. The study population consisted of 86 consecutive… read more here.
Keywords: serum caspase; severe sepsis; caspase cleaved;
Improving Recognition of Pediatric Severe Sepsis in the Emergency Department: Contributions of a Vital Sign–Based Electronic Alert and Bedside Clinician Identification
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Emergency Medicine"
DOI: 10.1016/j.annemergmed.2017.03.019
Abstract: Study objective Recognition of pediatric sepsis is a key clinical challenge. We evaluate the performance of a sepsis recognition process including an electronic sepsis alert and bedside assessment in a pediatric emergency department (ED). Methods… read more here.
Keywords: sepsis; electronic sepsis; severe sepsis; recognition ... See more keywords
Outcome of Immediate Versus Early Antibiotics in Severe Sepsis and Septic Shock: A Systematic Review and Meta-analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of emergency medicine"
DOI: 10.1016/j.annemergmed.2020.04.042
Abstract: STUDY OBJECTIVE Debate exists about the mortality benefit of administering antibiotics within either 1 or 3 hours of sepsis onset. We performed this meta-analysis to analyze the effect of immediate (0 to 1 hour after… read more here.
Keywords: sepsis; sepsis septic; severe sepsis; septic shock ... See more keywords
Implications of Centers for Medicare & Medicaid Services Severe Sepsis and Septic Shock Early Management Bundle and Initial Lactate Measurement on the Management of Sepsis
Sign Up to like & getrecommendations! Published in 2018 at "Chest"
DOI: 10.1016/j.chest.2018.03.025
Abstract: Background Sepsis remains a significant cause of morbidity and mortality in the United States, leading to the implementation of the Severe Sepsis and Septic Shock Early Management Bundle (SEP‐1). SEP‐1 identifies patients with “severe sepsis”… read more here.
Keywords: sepsis; severe sepsis; lactate; management ... See more keywords
Immunoparalysis: Clinical and immunological associations in SIRS and severe sepsis patients
Sign Up to like & getrecommendations! Published in 2017 at "Cytokine"
DOI: 10.1016/j.cyto.2017.01.012
Abstract: Introduction: This study was designed to identify changes in the monocytic membrane marker HLA‐DR and heat shock proteins (HSPs) in relation to T‐regulatory cells (T‐regs) and other immunological marker changes in patients with systemic inflammatory… read more here.
Keywords: sepsis; severe sepsis; cd14 hla; sirs severe ... See more keywords
Higher versus standard amikacin single dose in emergency department patients with severe sepsis and septic shock: a randomised controlled trial.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2017.11.009
Abstract: Recent studies suggest that intensive care unit patients treated with amikacin frequently do not attain the desired pharmacokinetic/pharmacodynamic (PK/PD) target, i.e. peak amikacin concentration (Cpeak) to minimum inhibitory concentration (MIC) ratio of ≥8, when a… read more here.
Keywords: sepsis septic; severe sepsis; septic shock; target ... See more keywords
The effect of early goal‐directed therapy for treatment of severe sepsis or septic shock: A systemic review and meta‐analysis☆,☆☆
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Critical Care"
DOI: 10.1016/j.jcrc.2016.10.019
Abstract: Purpose: To assess the effects of early goal‐directed therapy (EGDT) on reducing mortality compared with conventional management of severe sepsis or septic shock. Materials and methods: We included a systemic review, using the Medline and… read more here.
Keywords: directed therapy; sepsis; early goal; severe sepsis ... See more keywords
The impact of organ dysfunctions on mortality in patients with severe sepsis: A multicenter prospective observational study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Critical Care"
DOI: 10.1016/j.jcrc.2018.03.011
Abstract: Purpose: Disseminated intravascular coagulations (DIC), acute respiratory distress syndrome (ARDS), and acute kidney injury (AKI) are major organ dysfunctions that occur in patients with sepsis. This study aimed to elucidate the impact of these organ… read more here.
Keywords: sepsis; patients severe; severe sepsis; organ dysfunctions ... See more keywords
Right‐to‐left ventricular end diastolic diameter ratio in severe sepsis and septic shock
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Critical Care"
DOI: 10.1016/j.jcrc.2018.09.025
Abstract: Purpose: The ratio of right ventricular end‐diastolic diameter (EDD) to left ventricular EDD (RV/LV) is a measure predictive of right ventricular failure. We hypothesized that an increase in RV/LV would be associated with poor prognosis… read more here.
Keywords: septic shock; severe sepsis; sepsis septic; ventricular end ... See more keywords